Cardiovascular Modelling

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Morbiducci U, Gallo D, Massai D, Ponzini R, Deriu MA, Antiga L, Redaelli A, Montevecchi FM. On the importance of blood rheology for bulk flow in hemodynamic models of the carotid bifurcation. J Biomech 2011; 44(13):2427-38. [PubMed]

Maisano F, Taramasso M, Guidotti A, Redaelli A, Fiore GB, Baroni G, Patete P, Alfieri O. Simulation of Functional Tricuspid Regurgitation Using an Isolated Porcine Heart Model. J Heart Valve Dis 2011; 20:657-663.

Dubini G, Ambrosi D, Bagnoli P, Boschetti F, Caiani EG, Chiastra C, Conti CA, Corsini C, Costantino ML, D'Angelo C, Formaggia L, Fumero R, Gastaldi D, Migliavacca F, Morlacchi S, Nobile F, Pennati G, Petrini L, Quarteroni A, Redaelli A, Stevanella M, Veneziani A, Vergara C, Votta E, Wu W, Zunino P. Trends in biomedical engineering: focus on Patient Specific Modeling and Life Support Systems. J Appl Biomater Biomech 2011; 9(2):109-17. [PubMed]

Mangini A, Lemma MG, Soncini M, Votta E, Contino M, Vismara R, Redaelli A, Antona C. The aortic interleaflet triangles annuloplasty: a multidisciplinary appraisal. Eur J Cardiothorac Surg 2011; 40(4):851-7. [PubMed]

Stevanella M, Krishnamurthy G, Votta E, Swanson JC, Redaelli A, Ingels NB. Mitral leaflet modeling: Importance of in vivo shape and material properties. J Biomech 2011; 44(12):2229-2235. [PubMed]

Vismara R, Antona C, Mangini A, Cervo M, Contino M, Bosisio E, Redaelli A, Fiore GB. In vitro study of aortic valves treated with neo-chordae grafts: hydrodynamics and tensile force measurements. Ann Biomed Eng. 2011; 39(3):1024-31. [PubMed]

Vismara R, Pavesi A, Votta E, Taramasso M, Maisano F, Fiore GB. A pulsatile simulator for the in vitro analysis of the mitral valve with tri-axial papillary muscle displacement. Int J Artif Organs 2011; 34(4):383-391. [PubMed]

Conti CA, Votta E, Corsi C, De Marchi D, Tarroni G, Stevanella M, Lombardi M, Parodi O, Caiani EG, Redaelli A. Left ventricular modelling: a quantitative functional assessment tool based on CMR imaging. Interface Focus 2011; 1:384–395.

Stevanella M, Maffessanti F, Conti CA, Votta E, Arnoldi A, Lombardi M, Parodi O, Caiani EG, Redaelli A.  Mitral Valve Patient-Specific Finite Element Modeling from Cardiac MRI: Application to an Annuloplasty Procedure. Cardiovascular Engineering and Technology 2011; 2(2): 66–76.

Vismara R, Fiore GB. Beat-rate dependent mitral flow patterns for in vitro hemodynamic applications.Int J Artif Organs 2010;33(12):868-76. [PubMed]

Votta E, Vismara R, Redaelli A, Arcobasso L, Maisano F, Alfieri O, Fiore GB. Response of two annular prostheses to functional mitral regurgitation main determinants: an in vitro evaluation. ASAIO J. 2010; 56(6):491-6. [PubMed]

Redaelli A, Fiore GB, Vesentini S, Ponzini R, Morbiducci U. Multiscale and integrative modeling. In: Fluid dynamics of biological flows. M.L. Riethmuller & P. Corieri (eds.), The von Karman Institute for Fluid Dynamics, Rhode-St-Genèse (B): 1-45, 2010.

Morbiducci U, Ponzini R, Rizzo G, Cadioli M, Esposito A, Montevecchi FM, Redaelli A. Mechanistic insight into the physiological relevance of helical blood flow in the human aorta: an in vivo study. Biomech Model Mechanobiol. 2011; 10(3):339-55. [PubMed]

Morbiducci U, Gallo D, Ponzini R, Massai D, Antiga L, Montevecchi FM, Redaelli A. Quantitative Analysis of Bulk Flow in Image-Based Hemodynamic Models of the Carotid Bifurcation: The Influence of Outflow Conditions as Test Case. Ann Biomed Eng. 2010; 38(12):3688-705. [PubMed]

Stevanella M, Votta E, Lemma M, Antona C, Redaelli A. Finite element modelling of the tricuspid valve: A preliminary study. Med Eng Phys. 2010; 32(10):1213-23. [PubMed]

Morbiducci U, Gallo D, Massai D, Consolo F, Ponzini R, Antiga L, Bignardi C, Deriu MA, Redaelli A. Outflow conditions for image-based hemodynamic models of the carotid bifurcation: implications for indicators of abnormal flow. J Biomech Eng. 2010; 132:091005. [PubMed]

Vergara C, Ponzini R, Veneziani A, Redaelli A, Neglia D, Parodi O. Womersley number-based estimation of flow rate with Doppler ultrasound: Sensitivity analysis and first clinical application. Comput Methods Programs Biomed. 2010; 98:151-60. [PubMed]

Conti CA, Votta E, Della Corte A, Del Viscovo L, Bancone C, Cotrufo M, Redaelli A. Dynamic finite element analysis of the aortic root from MRI-derived parameters. Med Eng Phys. 2010; 32:212-221. [PubMed]

Conti CA, Della Corte A, Votta E, Del Viscovo L, Bancone C, De Santo LS, Redaelli A. Biomechanical Implications of the Congenital Bicuspid Aortic Valve: a Finite Element Study of Aortic Root Function from In Vivo Data. J Thorac Cardiovasc Surg 2010; 140:890-6. [PubMed]

Vismara R, Fiore GB, Mangini A, Contino M, Lemma M, Redaelli A, Antona C. A novel approach to the in vitro hydrodynamic study of the aortic valve: mock loop development and test. ASAIO J. 2010, 56:279-84. [PubMed]

Ponzini R, Vergara C, Rizzo G, Veneziani A, Roghi A, Vanzulli A, Parodi O, Redaelli A. Womersley number-based estimates of blood flow rate in Doppler analysis: in vivo validation by means of phase-contrast MRI. IEEE Trans Biomed Eng. 2010, 57:1807-15. [PubMed]

Morbiducci U, Ponzini R, Nobili M, Massai D, Montevecchi FM, Bluestein D, Redaelli A. Blood damage safety of prosthetic heart valves. Shear-induced platelet activation and local flow dynamics: a fluid-structure interaction approach. J Biomech. 2009; 42:1952-60.

Stevanella M, Votta E, Redaelli A. Mitral valve finite element modeling: implications of tissues' nonlinear response and annular motion. J Biomech Eng. 2009; 131(12):121010. [PubMed]

Soncini M, Votta E, Zinicchino S, Burrone V, Mangini A, Lemma M, Antona C, Redaelli A. Aortic root performance after valve sparing procedure: A comparative finite element analysis. Med Eng Phys. 2009; 31, 234-243.

Morbiducci U, Ponzini R, Rizzo G, Cadioli M, Esposito A, Cobelli F, Del Maschio F, Montevecchi FM, Redaelli A. In Vivo Quantification of Helical Blood Flow in Human Aorta by Time-Resolved Three-Dimensional Cine Phase Contrast Magnetic Resonance Imaging. Ann. Biomed. Eng. 2009; 3:516-531.

Ponzini R, Rizzo G, Vergara C, Veneziani A, Morbiducci U, Montevecchi FM, Redaelli A. Computational modeling of local hemodynamics phenomena: methods, tools and clinical applications, Nuovo Cimento C della Società Italiana di Fisica - Colloquia on Physics 2009; 32:77-80.

Nobili M, Sheriff J, Morbiducci U, Redaelli A, Bluestein D. Platelet Activation Due to Hemodynamic Shear Stresses: Damage Accumulation Model and Comparison to in vitro Measurements. ASAIO J. 2008; 54:64-72.

Votta E, Caiani E, Veronesi F, Soncini M, Montevecchi FM, Redaelli A. Mitral valve finite-element modelling from ultrasound data: a pilot study for a new approach to understand mitral function and clinical scenarios. Philos Transact A Math Phys Eng Sci. 2008; 366:3411-34.

Nobili M, Morbiducci U, Ponzini R, Del Gaudio C, Balducci A, Grigioni M, Maria Montevecchi F, Redaelli A. Numerical simulation of the dynamics of a bileaflet prosthetic heart valve using a fluid-structure interaction approach. J Biomechanics, 2008; 41:2539-50.

Ponzini R, Lemma M, Morbiducci U, Montevecchi FM, Redaelli A. Doppler derived quantitative flow estimate in coronary artery bypass graft: a computational multiscale model for the evaluation of the current clinical procedure. Med Eng Phys. 2008; 30:809-16.

Morbiducci U, Lemma M, Ponzini R, Boi A, Bondavalli L, Antona C, Montevecchi FM, Redaelli A. Does the Ventrica magnetic vascular positioner (MVP(R)) for coronary artery bypass grafting significantly alter local fluid dynamics? A numeric study. Int J Artif Organs. Wichtig Ed., Milano, ISSN: 1724-6040, 2007; 30:628-39.

Morbiducci U, Ponzini R, Grigioni M, Redaelli A. Helical flow as fluid dynamic signature for atherogenesis risk in aortocoronary bypass. A numeric study. J Biomech. 2007; 40(3):519-534.

Nobili M, Passoni G, Redaelli A. Two fluid-structure approaches for 3D simulation of St. Jude Medical bileaflet valve opening. Journal of Applied Biomaterials & Biomechanics 2007; 5:49-59.

Votta E, Maisano F, Bolling S F, Alfieri O, Montevecchi F M, Redaelli A. The Geoform Disease-Specific Annuloplasty System: A Finite Element Study. Ann Thorac Surg. 2007; 84:92-102.

Rasponi M, Fiore GB, Redaelli A, Montevecchi FM, Fumero R. A reliable method for prototyping flexible physiologic-like behaving left ventricles for studying mitral valve surgical corrections. Journal of Mechanics in Medicine and Biology 2006; 6(1):101-107.

Soncini M, Votta E, Zinicchino S, Burrone V, Fumero R, Mangini A, Lemma M, Antona C, Redaelli A. Finite element simulations of the physiological aortic root and valve sparing corrections. Journal of Mechanics in Medicine and Biology 2006; 6(1):91-99.

Fiore GB, Soncini M, Vesentini S, Penati A, Visconti G, Redaelli A. Multi-scale analysis of the Toraymyxin adsorption cartridge. Part II: Computational fluid-dynamic study. Int J Artif Organs. 2006; 29(2):251-260.

Ponzini R, Vergara C, Redaelli A, Veneziani A. Reliable CFD-based estimation of flow rate in haemodynamics measures. Ultrasound Med Biol. 2006; 32:1545-1555.

Maisano F, Redaelli A, Soncini M, Votta E, Arcobasso L, Alfieri O. An annular prosthesis for the treatment of functional mitral regurgitation: finite element model analysis of a dog bone-shaped ring prosthesis. Ann Thorac Surg. 2005; 79(4):1268-75.

Redaelli A, Maisano F, Ligorio G, Cattaneo E, Montevecchi FM, Alfieri O. Flow dynamics of the St Jude Medical Symmetry aortic connector vein graft anastomosis do not contribute to the risk of acute thrombosis. J Thorac Cardiovasc Surg. 2004 Jul;128(1):117-23.

Redaelli A, Bothorel H, Votta E, Soncini M, Morbiducci U, Del Gaudio C, Balducci A, Grigioni M. 3-D simulation of the St. Jude Medical bileaflet valve opening process: fluid-structure interaction study and experimental validation. J Heart Valve Dis. 2004;13(5):804-13.

Redaelli A, Maisano F, Soncini M, Alfieri O, Montevecchi FM. Haemodynamics and mechanics following partial left ventriculectomy: a computer modeling analysis. Med Eng Phys. 2004 Jan;26(1):31-42.

Votta E, Maisano F, Soncini M, Redaelli A, Montevecchi FM, Alfieri O. 3-D computational analysis of the stress distribution on the leaflets after edge-to-edge repair of mitral regurgitation. J Heart Valve Dis. 2002; 11:810-22.

Redaelli A, Guadagni G, Fumero R, Maisano F, Alfieri O. A computational study of the hemodynamics after "edge-to-edge" mitral valve repair. J. Biomech. Eng. 2001; 123:565-570.

Di Martino E, Guadagni G, Fumero A, Ballerini G, Spirito R, Biglioli P, Redaelli A. Fluid-structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm. Medical Engineering & Physics 2001; 23:647-655.

Di Martino E, Redaelli A, Guadagni G, Fumero A, Spirito E. Realistic 3D model of aortic aneurysms obtained from CT scans image processing. A computational study of the fluid-structure interaction within the aneurysmatic vessel. In Computer Methods in Biomechanics and Biomedical Engineering. Middleton J., Pande G.N., Jones M.L. (eds.). Gordon and Breach Science Publishers, 719-724, 2001.

Soncini M, Manfred G, Redaelli A, Attanasio A, Tosoni A, Venturino M, Susini G. A computerized method to measure systolic pressure variation (SPV) in mechanically ventilated patients. J Clin Monit Comput. 2002; 17(2):141-6.

Redaelli A, Maisano F, Schreuder JJ, Montevecchi FM. Ventricular motion during the ejection phase: a computational analysis. J. Appl. Physiol. 2000; 89:314-22.

Redaelli A, Montevecchi FM. Ventricular mechanics during the ejection phase. In: Intra and extracorporeal cardiovascular fluid dynamics Vol.2 Computational Fluid-structure Interaction in the Cardiovascular System . Verdonck P. and Perktold K. (eds.). WIT Press, Southampton, UK, 129-175, 2000.

Maisano F, Redaelli A, Pennati G, Fumero R, Torracca L, Alfieri O. The hemodynamic effects of double orifice valve repair for mitral regurgitation: a 3-D computational model. Eur. J. Cardio-thoracic Surg. 1999; 15:419-425.

Redaelli A, Montevecchi FM. Intraventricular pressure drop and aortic blood acceleration as indices of cardiac inotropy: a comparison with the first derivative of aortic pressure based on computer fluid dynamics. Med. Eng. Phys. 1998; 20:231-241.

Redaelli A, Di Martino E, Mantero S, Agazzi A, Vangeri E, Gamba A, Fumero R. Optimisation of a stentless valve prosthesis based on an analytic parametric model of the aortic valve. Int. J. Of Artificial Organs 1998; 21:161-170.

Migliavacca F, Kilner PJ, Dubini G, Pennati G, Redaelli A. Localised peaks of computer flow velocity through asymmetric mild stenoses in large vessel models suggest wide scope for error in "pressure gradient" estimation. J. Vasc. Investig. 1997; 3:17-25.

Redaelli A, Boschetti F, Inzoli F. The assignement of velocity profiles in finite element simulations of pulsatile flow in arteries. Comp. Biol and Med. 1997; 27:233-247.

Redaelli A, Pietrabissa R. A structural model of the left ventricle including muscle fibres and coronary vessels: mechanical behaviour in normal conditions. Meccanica 1997; 32:53-70.

Redaelli A, Di Martino E, Procopio AM, Gamba A, Fumero R. Assessment of the influence of the compliant aortic root on aortic valve mechanics by means of a geometrical model. Medical Engineering & Physics 1997; 19:696-71.

Inzoli F, Di Martino E, Dubini G, Redaelli A, Fumero R. Biomechanics of abdominal aortic aneurysm in the presence of endoluminal thrombus: experimental and computational study. Int. J. Of Artificial Organs 1996; 19, 359-66.

Redaelli A, Montevecchi FM. Computational evaluation of intraventricular pressure gradients based on a fluid-structure approach. J. Biomech. Eng 1996; 118: 529-537.




Micro- and Bio- Fluid Dynamics

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Pennella F, Rossi M, Ripandelli S, Rasponi M, Mastrangelo F, Deriu MA, Ridolfi L, Kähler CJ, Morbiducci U. Numerical and experimental characterization of a novel modular passive micromixer. Biomed Microdevices. 2012. [Epub ahead of print].[PubMed]

Piraino F, Camci-Unal G, Hancock MJ, Rasponi M, Khademhosseini A. Multi-gradient hydrogels produced layer by layer with capillary flow and crosslinking in open microchannels. Lab Chip 2012; 12(3):659-61.[PubMed]

Boccafoschi F, Rasponi M, Mosca C, Bocchi E, Vesentini S. Study of cellular adhesion by means of micropillar surface topologies. Advanced Materials Research 2012; 409:105-110.

Biffi E, Piraino F, Pedrocchi A, Fiore GB, Ferrigno G, Redaelli A, Menegon A, Rasponi M. A microfluidic platform for controlled biochemical stimulation of twin neuronal networks. Biomicrofluidics. 2012; 6(2):24106-2410610.[PubMed]

Biffi E, Menegon A, Piraino F, Pedrocchi A, Fiore GB, Rasponi M. Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates. 2011. Biotechnol Bioeng 2012; 109(1):166-75. [PubMed]

Hancock MJ*, Piraino F*, Camci-Unal G*, Rasponi M, Khademhosseini A. Anisotropic material synthesis by capillary flow in a fluid stripe. Biomaterials 2001; 32(27):6493-504. [PubMed]

Selimović Ś*, Piraino F*, Bae H, Rasponi M, Redaelli A, Khademhosseini A. Microfabricated polyester conical microwells for cell culture applications. Lab on a Chip 2011; 11(14):2325-32. [PubMed]

Pavesi A, Piraino F, Fiore GB, Farino MK, Moretti M, Rasponi M: How to embed three-dimensional flexible electrodes in microfluidic devices for cell culture applications. Lab on a Chip 2011; 11(9):1593-5. [PubMed]

Rasponi M, Piraino F, Sadr N, Laganà M, Redaelli A, Moretti M. Reliable magnetic reversible assembly of complex microfluidic devices: fabrication, characterization, and biological validation. Microfluidics and Nanofluidics 2011; 10(5):1097-1107.

Rasponi M, Ullah T, Gilbert RJ, Fiore GB, Thorsen TA. Realization and efficiency evaluation of a micro-photocatalytic cell prototype for real-time blood oxygenation. Med Eng Phys 2011; 33(7):887-92. [PubMed]

Fiore GB, Soncini M, Vesentini S, Redaelli A. Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow: hydrodynamics of sorption. Contrib Nephrol. 2010; 167:55-64. [PubMed]

Vesentini S, Soncini M, Fiore GB, Redaelli A. Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow: molecular interactions. Contrib Nephrol. 2010; 167:45-54. [PubMed]

Fiore GB, Morbiducci U, Ponzini R, Redaelli A. Bubble tracking through computational fluid dynamics in arterial line filters for cardiopulmonary bypass. ASAIO J. 2009; 55:438-44.

Vismara R, Laganà K, Migliavacca F , Schievano S, Coats L, Taylor A, Bonhoeffer P. Experimental set-up to evaluate the performance of percutaneous pulmonary valved stent in different outflow tract morphologies. Artif Organs 2009; 33:46-53.

Lanzarone E, Vismara R, Fiore GB. A new pulsatile volumetric device with biomorphic valves for the in vitro study of the cardiovascular system. Artif Organs 2009; 33:1048-62.

Gilbert JR, Park H, Rasponi M, Redaelli A, Gellman B, Dasse KA, Thorsen T. Computational and Functional Evaluation of a Microfluidic Blood Flow Device. ASAIO J 2007; 53:447-55.

Fiore GB, Ronco C. Principles and practice of internal hemodiafiltration. Contrib Nephrol. 2007; 158:177-184.

Fiore GB, Guadagni G, Lupi A, Ricci Z, Ronco C. A new semiempirical mathematical model for prediction of internal filtration in hollow fiber hemodialyzers. Blood Purificat. 2006; 24:555-568.

Fiore GB, Ronco C. Mathematical model to characterize internal filtration. Contrib Nephrol. 2005; 149:27-34.

Bagnoli P, Vismara R, Fiore GB, Costantino ML.A mechanical model lung for hydraulic testing of total liquid ventilation circuits. Int J Artif Organs. 2005; 28:1232-1241.

Costantino ML, Bagnoli P, Dini G, Fiore GB, Soncini M, Corno C, Acocella F, Colombi R. Pressure drop vs flow relationship in isolated preterm lamb tracheae. Journal of Applied Biomaterials & Biomechanics 2004; 2:177 - 182.

Pennati G, Fiore GB, Lagana K, Fumero R. Mathematical modeling of fluid dynamics in pulsatile cardiopulmonary bypass. Artif Organs 2004; 28: 196-209.

Corno C, Fiore GB, Costantino ML. A mathematical model of neonatal tidal liquid ventilation integrating airway mechanics and gas transfer phenomena. IEEE Trans Biomed Eng 2004; 51:604-611.

Fiore GB, Ronco C. Internal hemodiafiltration (iHDF): a possible option to expand hemodiafiltration therapy. Int J Artif Organs 2004; 27:420-423 (editorial comment).

Costantino ML, Bagnoli P, Dini G, Fiore GB, Soncini M, Corno C, Acocella F, Colombi R. A numerical and experimental study of compliance and collapsibility of preterm lamb tracheae. J Biomech 2004; 37:1837-1847.

Corno C, Fiore GB, Martelli E, Dani C, Costantino ML. Volume controlled apparatus for neonatal tidal liquid ventilation. ASAIO J 2003; 49: 250-258.

Mantero S, Longo I, Fiore GB, Severini A. Hyperthermia in the treatment of cholangiocarcinoma: development and testing of an endobiliary microwave device. Cardiovasc Intervent Radiol 2003; 26:379-385.

Dani C, Costantino ML, Martelli E, Corno C, Fiore GB, Buonocore G, Longini M, Di Filippo A, Tozzini S, Rubaltelli FF. Perfluorocarbons attenuate oxidative lung damage. Pediatr Pulmonol 2003; 36:322-32.

Fiore GB, Redaelli A, Guadagni G, Inzoli F, Fumero R. Development of a new disposable pulsatile pump for cardiopulmonary bypass: CFD design and in vitro tests. ASAIO J 2002, 48:260-267.

Raimondi MT, Boschetti F, Falcone L, Fiore GB, Remuzzi A, Marinoni E, Marazzi M, Pietrabissa R. Mechanobiology of engineered cartilage cultured under a quantified fluid dynamic environment. Biomech Model Mechanobiol 2002, 1:69-82.

Fiore GB, Grigioni M, Daniele C, D'Avenio G, Barbaro V, Fumero R. Hydraulic functional characterisation of aortic mechanical heart valve prostheses through lumped parameter modelling. J Biomech 2002, 35:1427-1432.

Pennati G, Fiore GB, Migliavacca F, Lagana' K, Dubini G, Fumero R. In vitro steady-flow analysis of systemic-to-pulmonary shunt haemodynamics. J Biomech 2001, 34:23-30.

Costantino ML, Fiore GB. A model of neonatal tidal liquid ventilation mechanics. Med Eng & Physics 2001; 23:457-47.

Fiore GB, Costantino ML, Fumero R, Montevecchi FM. The pumping oxygenator: design criteria and first in vitro results. Artif Organs 2000, 24:797-80.

Pennati G, Fiore GB, Inzoli F, Mastrantonio F, Galavotti D, Fini M. Mass transfer efficiency of a commercial hollow fibre oxygenator during six-hour in vitro perfusion with steady and with pulsatile blood flow. Int J Artif Organs 1998; 21:97-106.

Fiore GB, Pennati G, Inzoli F, Mastrantonio F, Galavotti D. Effects of blood flow pulse frequency on mass transfer efficiency of a commercial hollow fibre oxygenator. Int J Artif Organs 1998; 21:535-54.

Costantino ML, Fiore GB. Liquid ventilation: a mathematical model of gas diffusion in the premature lung. Med Eng & Physics 1997; 19:157-16.

Costantino ML, Fiore GB. Normalization of experimental results with respect to inlet conditions in membrane oxygenator testing. Perfusion 1996; 11:65-71.




Molecular Modeling

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Gautieri A, Vesentini S, Redaelli A, Buehler M. Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up. Nano Lett 2011;11(2):757-66. [PubMed]

Deriu MA, Bidone TC, Mastrangelo F, Di Benedetto G, Soncini M, Montevecchi FM, Morbiducci U. Biomechanics of actin filaments: a computational multi-level study. J Biomech 2011; 44(4):630-6. [PubMed]

Gautieri A, Vesentini S, Redaelli A. How to predict diffusion of medium-sized molecules in polymer matrices. From atomistic to coarse grain simulations. J Mol Model 2010; 16(12):1845-51. [PubMed]

Gautieri A, Russo A, Vesentini S, Redaelli A, Buehler MJ. Coarse-grained model of collagen molecules using an extended MARTINI force field. J Chem Theory Comput 2010; 6:1210–1218.

Gautieri A, Ionita M, Silvestri D, Votta E, Vesentini S, Fiore GB, Barbani N, Ciardelli G, Redaelli A. Computer-Aided Molecular Modeling and experimental validation of water permeability properties in biosynthetic materials. J Comput Theor Nanosci 2010; 7: 1287-1293.

Nova A, Keten S, Pugno NM, Redaelli A, Buehler MJ. Molecular and Nanostructural Mechanisms of Deformation, Strength and Toughness of Spider Silk Fibrils. Nano Lett. 2010, 10:2626-34. [PubMed]

Aprodu I, Soncini M, Montevecchi FM, Redaelli A. Mechanical characterization of actomyosin complex by molecular mechanics simulations. J Appl Biomater Biomech. 2010, 8:20-7. [PubMed]

Deriu MA, Soncini M, Orsi M, Patel M, Essex JW, Montevecchi FM, Redaelli A. Anisotropic Elastic Network Modeling of Entire Microtubules. Biophys J, 2010, 99:2190-99. [PubMed]

Gautieri A, Uzel S, Vesentini S, Redaelli A, Buehler M. Molecular and mesoscale mechanisms of Osteogenesis Imperfecta disease in collagen fibrils. Biophysical Journal 2009; 97:857-65.

Gautieri A, Vesentini S, Redaelli A, Buehler MJ. Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains. Protein Sci. 2009; 18:161-8.

Enemark S, Deriu MA, Soncini M, Redaelli A. Mechanical model of the tubulin dimer based on molecular dynamics simulations. Journal of Biomechanical Engineering 2008; 130:1-7.

Gautieri A, Buehler MJ, Redaelli A. Deformation rate controls elasticity and unfolding pathway of single tropocollagen molecules. J Mech Behav Biomed Mater. 2009; 2:130-7.

Soncini M, Votta E, Aprodu I, Enemark S, Redaelli A, Deriu MA, Montevecchi FM. Microtubule-kinesin mechanics by molecular modelling. Biophysical Reviews and Letters 2009; 4:45-62.

Gautieri A, Vesentini S, Buehler MJ, Redaelli A. Intermolecular slip mechanism in tropocollagen nanofibrils. Journal of Materials Research 2009; 100:921-925.

Aprodu I, Redaelli A, Soncini M. Actomyosin Interaction: Mechanical and Energetic Properties in Different Nucleotide Binding States. Int. J. Mol. Sci. 2008; 9: 1927-1943.

Aprodu I, Soncini M, Redaelli A. Interaction forces and interface properties of KIF1A kinesin-alphabeta tubulin complex assessed by molecular dynamics. J Biomechanics, 2008 41:3196-201.

Gautieri A, Vesentini S, Montevecchi FM, Redaelli A. Mechanical properties of physiological and pathological models of collagen peptides investigated via steered molecular dynamics simulations. J Biomechanics, 2008; 41: 3073–3077.

Aprodu I., Soncini M., Redaelli A. Mechanical characterization of the motor proteins - a molecular dynamics approach. Macromolecular Theory and Simulation, 2008; 17:376-384.

Soncini M, Vesentini S, Ruffoni D, Orsi M, Deriu MA, Redaelli A. Mechanical response and conformational changes of alpha-actinin domains during unfolding: a molecular dynamics study. Biomech Model Mechanobiol 2007; 6: 399-407.

Deriu MA, Enemark S, Soncini M, Montevecchi FM, Redaelli A. Tubulin: From Atomistic Structure to Supramolecular Mechanical Properties. J Mater Sci. Springer New York (US), ISSN: 0022-2461, 2007, 42: 8864–8872, 2007.

Redaelli A, Soncini M, Vesentini S, Votta E, Deriu M, Gautieri A, Fiore GB, Montevecchi FM, Enemark S, Aprodu I, Ionita M. Multiscale modelling in biomechanical applications. In Nanomechanics in Italy, 2007, Ed. Nicola M. Pugno, Kerala, India.

Vesentini S, Soncini M, Zaupa A, Silvestri V, Fiore GB, Redaelli A. Multi-scale analysis of the Toraymyxin adsorption cartridge. Part I: molecular interaction of polymyxin B with endotoxins. Int J Artif Organs. 2006, 29 (2): 239-250.

Vesentini S, Montevecchi FM, Redaelli A. CAMM techniques for the prediction of the mechanical properties of tendons and ligaments nanostructures. ScientificWorldJournal. 2005 Jul 22;5:564-70.

Vesentini S, Fitie CF, Montevecchi FM, Redaelli A. Molecular assessment of the elastic properties of collagen-like homotrimer sequences. Biomech Model Mechanobiol. 2005 Jun;3(4):224-34. Epub 2005 Apr 12.

Vesentini S, Redaelli A, Montevecchi FM. Estimation of the binding force of the collagen molecule-decorin core protein complex in collagen fibril. J Biomech. 2005 Mar;38(3):433-43.

Vesentini S, Montevecchi FM, Redaelli A. Characterization of mechanical properties of ECM nanostructures of tendons and ligaments. In Recent Research and Developments in Biomechanics 2, Ed. Pandalai SG , Transworld Research Network, Kerala, India, 55- 77.

Soncini M, Redaelli A, Montevecchi FM. Myosin head mechanical performance under different conformational change mechanisms. J Biomech. 2004 Jul;37(7):1031-41.

Redaelli A, Vesentini S, Soncini M, Vena P, Mantero S, Montevecchi FM. Possible role of decorin glycosaminoglycans in fibril to fibril force transfer in relative mature tendons--a computational study from molecular to microstructural level. J Biomech. 2003 36(10):1555-69.

Mantero S, Piuri D, Montevecchi FM, Vesentini S, Ganazzoli F, Raffaini G. Albumin adsorption onto pyrolytic carbon: a molecular mechanics approach. Journal of Biomedical Materials Research (2002) 59: 329-339.

Redaelli A., Soncini M., Montevecchi F.M. Myosin cross-bridge mechanics: geometrical determinants for continuous sliding. J. Biomechanics, 34(12), 1607-1617, 2001.

Redaelli A., Soncini M., Montevecchi F. The actin-myosin complex: from architecture to mechanical function. GAMACIn Mechano Transduction 2000 -. Engineering and Biological Materials and Structure. Ribreau C., Berthaud Y., Moreau M.R., Ratier L., Renaudeaux J.P., Thiriet M., Wendling S. (eds.). GAMAC, Paris, 223-230, 2000.




Tissue Engineering

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Consolo F, Bariani C, Mantalaris A, Montevecchi F, Redaelli A, Morbiducci U. Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells. Biomech Model Mechanobiol. 2011 Apr 23. [PubMed]

Vismara R, Soncini M, Talò G, Dainese L, Guarino A, Redaelli A, Fiore GB. A Bioreactor with Compliance Monitoring for Heart Valve Grafts. Ann Biomed Eng. 2010; 38:100-108. [PubMed]

Consolo F, Fiore GB, Truscello S, Caronna M, Morbiducci U, Montevecchi FM, Redaelli A. A Computational Model for the Optimization of Transport Phenomena in a Rotating Hollow-Fiber Bioreactor for Artificial Liver. Tissue Eng Part C Methods 2009; 15:41-55.

Cantini M, Fiore GB, Redaelli A, Soncini M. Numerical fluid-dynamic optimization of microchannel-provided porous scaffolds for the co-culture of adherent and non-adherent cells. Tissue Engineering Part A 2009; 15:615-623.

Couet F, Rajan N, Vesentini S, Mantovani D. Design of a collagen/silk mechano-compatible composite scaffold for the vascular tissue engineering: focus on compliance. Key Eng Mat. 2007; 334-335:1169-1172.

Amadori L, Rajan N, Vesentini S, Mantovani D. Atomic force and confocal microscopic studies of collagen-cell-based scaffolds for vascular tissue engineering. Adv Mat Res. 2007; 15-17:83-88.

Navarrini W, Canesi E, Cantini M, Resnati G, Metrangolo P, Uggeri F, Arcella V, Casati A, Masella M, Guala C, Ranzoni A, Sallemi L, Sciacca B, Scotti F. ASP studies on fluorine in biomedicine: two innovative applications. Supplement to Chemistry Today - Focus on Fluorine Chemistry. 2007; 25:48-50.

Boccafoschi F, Habermehl J, Vesentini S, Mantovani D. Biological performances of collagen-based scaffolds for vascular tissue engineering. Biomaterials. 2005; 26:7410-7.

Mantero S, Piuri D, Vesentini S, Montevecchi FM. Endothelial cell adhesion force estimation at the nanoscale. Journal of Applied Biomaterials & Biomechanics 2005; 3:42-49.

Vesentini S, Redaelli A, Montevecchi F.M. Skin nanostructural features determine suture biomechanics. IEEE Trans Nanobioscience. 2003 ; 2:79-88.




Fluid Mechanics

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Bozzi S, Passoni G. Mathematical modelling of bottom evolution by particle deposition and resuspension. Appl Math Model. 2012; doi:10.1016/j.apm.2011.11.048.

Bernardara P, de Rocquigny E, Goutal N, Arnaud A, Passoni G. Uncertainty analysis in flood hazard assessment: hydrological and hydraulic calibration. Can J Civ Eng. 2010; 37(7):968-979.

Bozzi S, Vedani M, Lotti D, Passoni G. Extrusion of aluminium hollow pipes: seam weld quality assessment via numerical simulation. Metallurgical Science and Technology 2009; 27(2):20-29.

Boscacci F, Passoni G. Logistica fluvio-marittima in Europa. La rilevanza europea del corridoio Adriatico, Franco Angeli, Milano, 2008.

Paparella F, Passoni G. Absence of Inelastic Collapse for a 1D Gas of Grains with an Internal Degree of Freedom. Comput Math Appl. 2008; 55:218-229.

von Hardenberg J, Parodi A, Passoni G, Provenzale A, Spiegel EA. Large scale patterns in Rayleigh-Benard convection. Phys Lett A 2008; 372:2223-2229.

De Michele C, Salvadori G, Passoni G, Vezzoli R. A multi-variate model of sea storms using copulas. Coast Eng. 2007; 54:734-751.

Rulli MC, Bozzi S, Spada M, Bocchiola D, Rosso R. Rainfall simulations on a fire disturbed Mediterranean area. J Hydrol. 2006;327:323-338.

Monti R, Colombo D, Graziano P, Passoni G. Indagini sperimentali sul contributo dei geosintetici per il contenimento dell’erosione. L’Ingegnere e l’Architetto 2006, 1-12/2006, 22-27.

Iovieno R, Passoni G, Tordella D. A new large-eddy simulation near-wall treatment. Phys Fluids 2004; 16(11):3935-3944.

Parodi A, von Hardenberg J, Passoni G, Provenzale A, Spiegel EA. Clustering of plumes in turbulent convection. Phys Rev Lett. 2004 May 14;92(19):194503. [Pubmed]

Bocchiola D, Catalano F, Menduni G, Passoni G. An Analytical-Numerical Approach to the Hydraulics of Floating Debris in River Channels. J Hydrol. 2002; 269:65-78.

Passoni G, Alfonsi G, Galbiati M. Analysis of Hybrid Algorithms for the Navier-Stokes Equation with respect to Hydrodynamic Stability Theory. Int J Numer Methods Fluids 2002; 38:1069-1089.

Passoni G, Cremonesi P, Alfonsi G. Analysis and Implementation of a Parallelization Strategy on a Navier-Stokes Solver for Shear Flow Simulations. Parallel Comput. 2001; 27:1665-1685.

Passoni G, Alfonsi G, Tula G, Cardu U. A wavenumber parallel computational code for the numerical integration of the Navier-Stokes equations. Parallel Comput. 1999; 25:593-611.

Alfonsi G, Passoni G, Pancaldo L, Zampaglione D. A Spectral-Finite Difference Solution of the Navier-Stokes Equations in 3-D. Int J Numer Methods Fluids 1998; 28:129-142.




Orthopaedic Biomechanics

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Soncini M, Vandini L, Redaelli A. Finite element analysis of a knee joint replacement during a gait cycle. Journal of Applied Biomaterials & Biomechanics 2004; 2: 45-54.

Caserta S, La Maida GA, Misaggi B, Peroni D, Pietrabissa R, Raimondi MT, Redaelli A. Elastic stabilization alone or combined with rigid fusion in spinal surgery: a biomechanical study and clinical experience based on 82 cases. Eur Spine J. 2002 Oct;11 Suppl 2:S192-7.

Soncini M, Pietrabissa R, Rodriguez y Baena R. Computational approach for the mechanical reliability of a dental implant. In Computer Methods in Biomechanics and Biomedical Engineering. Middleton J., Pande G.N., Jones M.L. (eds.). Gordon and Breach Science Publishers, 617-622, 2001.

Soncini M, Pietrabissa R. Computational simulation of the tooth movement during the orthodontic treatment. In Computer Methods in Biomechanics and Biomedical Engineering. Middleton J., Pande G.N., Jones M.L. (eds.). Gordon and Breach Science Publishers, 565-570, 2001.

Pietrabissa R, Contro R, Quaglini V, Soncini M, Gionso L, Simion M. Experimental and computational approach for the evaluation of biomechanical effects of dental bridge misfit. J. Biomechanics, 33, 1489-1495, 2000.

Manfredini P, Cocchetti G, Maier G, Redaelli A, Montevecchi FM. Poroelastic finite element analysis of a bone specimen under cyclic loading. J. Biomechanics, Elsevier Science, Oxford, UK, 32, 135-144, 1999.

Soncini M, Quaglini V, Pietrabissa R. Experimental method for the evaluation of the bone-fixture interface stability in dental implantology. Italian Journal of Oral Implantology. 1, 13-20, 1999.