{"id":732,"date":"2024-06-12T19:42:23","date_gmt":"2024-06-12T19:42:23","guid":{"rendered":"https:\/\/www.biomech.polimi.it\/?page_id=732"},"modified":"2024-10-24T22:26:30","modified_gmt":"2024-10-24T22:26:30","slug":"thlab_home","status":"publish","type":"page","link":"https:\/\/www.biomech.polimi.it\/?page_id=732","title":{"rendered":"ThLab_Home"},"content":{"rendered":"\n
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Platelet Function and Thrombogenicity<\/strong><\/strong><\/p>\n\n\n\n

Our research is devoted to the analysis of the thrombogenic potential of blood-contacting medical devices, with a specific emphasis on shear-mediated platelet activation. We also aim to develop point-of-care systems for bedside assessment of platelet function, enabling effective and efficient drug management to prevent thromboembolic complications.<\/p>\n<\/div><\/div>\n\n\n\n

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Thrombogenicity of blood contacting medical devices<\/strong><\/p>\n\n\n\n

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We integrate advanced computational and experimental techniques for optimizing the thrombogenic performance of cardiovascular devices.<\/p>\n\n\n\n

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Platelet function testing<\/strong><\/p>\n\n\n\n

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We develop point-of-care platelet aggregation systems by integrating microfluidics, electronics and impedance measurements<\/p>\n\n\n\n

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In vitro vascular models<\/strong><\/p>\n\n\n\n

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We design microfluidic vessel-on-a-chip platforms to study vascular pathologies, specifically focusing on interactions between platelets and endothelium.<\/p>\n\n\n\n

Our Projects<\/strong><\/p>\n\n\n\n

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In vitro thrombogenicity testing<\/strong><\/p>\n\n\n\n

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We use flow loop circuits replicating the clinical use of cardiovascular devices to assess their thrombogenicity with the platelet activity state (PAS) assay, which measures real-time thrombin production rates of activated platelets.<\/p>\n\n\n\n

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Platelet-on-chip technologies<\/strong><\/p>\n\n\n\n

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We develop lab-on-a-chip systems to facilitate platelet manipulation, including on-chip platelet separation from whole blood and platelet cell counting.<\/p>\n\n\n\n

Our Projects<\/strong><\/p>\n\n\n\n

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