{"id":741,"date":"2024-06-13T11:58:50","date_gmt":"2024-06-13T11:58:50","guid":{"rendered":"https:\/\/www.biomech.polimi.it\/?page_id=741"},"modified":"2024-10-24T22:25:49","modified_gmt":"2024-10-24T22:25:49","slug":"thlab_research","status":"publish","type":"page","link":"https:\/\/www.biomech.polimi.it\/?page_id=741","title":{"rendered":"THLab_Research"},"content":{"rendered":"\n<div class=\"wp-block-buttons alignfull is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-d445cf74 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" id=\"top\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"https:\/\/www.biomech.polimi.it\/?page_id=732\">Home<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"https:\/\/www.biomech.polimi.it\/?page_id=741\">Research<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"https:\/\/www.biomech.polimi.it\/?page_id=711\">People<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"https:\/\/www.biomech.polimi.it\/?page_id=1121\">Facilities<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"http:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/10\/tesi-biomech-2024-th.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Thesis<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"mailto:silvia.bozzi@polimi.it\">Contact us<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-cover alignfull\" style=\"padding-top:2%;min-height:230px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-30 has-background-dim\" style=\"background-color:#6c87cf\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"264\" class=\"wp-block-cover__image-background wp-image-1201\" alt=\"\" src=\"http:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/ThLab-main-cover.png\" data-object-fit=\"cover\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/ThLab-main-cover.png 1024w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/ThLab-main-cover-300x77.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/ThLab-main-cover-768x198.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-container-core-cover-is-layout-ee51f2d2 wp-block-cover-is-layout-constrained\">\n<div class=\"wp-block-group alignwide is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-5e763914 wp-block-group-is-layout-flex\" style=\"min-height:8rem\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-bea02a06 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center has-text-color\" style=\"color:#ffffff;margin-top:0rem;margin-bottom:1.01rem;font-size:clamp(2.071rem, 2.071rem + ((1vw - 0.2rem) * 2.98), 3.71rem);font-style:normal;font-weight:400;line-height:1;text-transform:capitalize\"><strong>Research Projects<\/strong><\/h2>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" style=\"color:#03081e;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-a370575b8d4d3f321b50d399f6b150c9\" id=\"innova\"><strong><strong>INNOVA<\/strong><\/strong>: <strong>Italian network of excellence for advanced diagnosis<\/strong>  <\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"3414\" height=\"2019\" src=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/1.-Immagine-INNOVA.png\" alt=\"\" class=\"wp-image-1250\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/1.-Immagine-INNOVA.png 3414w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/1.-Immagine-INNOVA-300x177.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/1.-Immagine-INNOVA-1024x606.png 1024w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/1.-Immagine-INNOVA-768x454.png 768w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/1.-Immagine-INNOVA-1536x908.png 1536w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/1.-Immagine-INNOVA-2048x1211.png 2048w\" sizes=\"auto, (max-width: 3414px) 100vw, 3414px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> Italian Ministry of Health<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2023-2027<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;PNC-E3-2022-23683266<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milano, Italy<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p>The Innova project is part of the PNRR-PNC initiative, aiming to support the scientific community by interfacing with clinical and industrial entities in the Life Sciences. It focuses on translational research and innovation for major human diseases by providing innovative diagnostic approaches across Italy.<\/p>\n\n\n\n<p>In collaboration with Ospedale Maggiore Policlinico&nbsp;and other centers in Italy, our team is part of WP 1, which investigates microvascular dysfunction of specific organs. Specifically, our work aims to develop and employ a microfluidic platform for studying microcirculation disorders. By integrating advanced technology and innovative research methods, the platform enables the modeling and analysis of microcirculatory conditions in different pathologies, highlighting relevant biomarkers for disease diagnostics and identifying common pathways. This tool is designed to facilitate a deeper understanding of these disorders, leading to improved diagnostic and therapeutic approaches.<\/p>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" style=\"color:#03081e;background-color:#e2f1ff;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-e77db1374c016b9606b982d060864b77\" id=\"pfo\"><strong>Migraine with aura and causal or incidental patent forame ovale (PFO): identification of biomarker(s) to select patients who would most benefit from PFO closure. The MANET study<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1867\" height=\"850\" src=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/3.-Immagine-PFO-1.png\" alt=\"\" class=\"wp-image-1255\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/3.-Immagine-PFO-1.png 1867w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/3.-Immagine-PFO-1-300x137.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/3.-Immagine-PFO-1-1024x466.png 1024w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/3.-Immagine-PFO-1-768x350.png 768w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/3.-Immagine-PFO-1-1536x699.png 1536w\" sizes=\"auto, (max-width: 1867px) 100vw, 1867px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> Italian Ministry of Health<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2022-2024<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;PNRR-MAD-2022-12376277<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Centro Cardiologico S.P.A. Fondazione Monzino<\/li>\n\n\n\n<li>IRCCS Policlinico San Donato<\/li>\n\n\n\n<li>Universit\u00e0 di Cagliari<\/li>\n\n\n\n<li>Azienda Ospedaliera Universitaria &#8220;Federico II&#8221;<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p>Migraine with aura (MHA) is a neurological disease associated with a multifactorial etiology and a prevalence of 12-15% in the general population. Several studies have described a strong relationship between migraine, and especially MHA and patent foramen ovale (PFO). This project aims to identify biomarkers able to discriminate migraineurs with PFO-related symptoms from those with incidental PFOs looking for distinctive features at the cellular\/molecular levels. To this end, we are developing a microfluidic platform based on computational hemodynamic simulations to evaluate blood cell activation in the specific mechanical environment of the PFO, i.e. by stimulating endothelium and blood cells with the specific shear stress profiles experienced during passage through the PFO.<\/p>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" style=\"color:#03081e;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-9d7f587c96666739aaa41ad10c6e3a3f\" id=\"aggregation\"><strong>Spontaneous Platelet Aggregation as a marker of platelet hyper-reactivity: functional characterization in a case-control study of patients with coronary artery disease and control subjects<\/strong>   <\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"3323\" height=\"1212\" src=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/2.-Immagine-Finalizzata-San-Paolo-1.png\" alt=\"\" class=\"wp-image-1254\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/2.-Immagine-Finalizzata-San-Paolo-1.png 3323w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/2.-Immagine-Finalizzata-San-Paolo-1-300x109.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/2.-Immagine-Finalizzata-San-Paolo-1-1024x373.png 1024w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/2.-Immagine-Finalizzata-San-Paolo-1-768x280.png 768w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/2.-Immagine-Finalizzata-San-Paolo-1-1536x560.png 1536w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/2.-Immagine-Finalizzata-San-Paolo-1-2048x747.png 2048w\" sizes=\"auto, (max-width: 3323px) 100vw, 3323px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> Italian Ministry of Health<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2019-2024<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;RF-2018-12367710<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Regione Lombardia \u2013 Direzione Generale Sanit\u00e0: ASST Santi Paolo e Carlo Medicina II, Presidio San Paolo<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p>The project aims to assess whether platelet hyper-reactivity, measured as the ability of platelets to spontaneously aggregate, is a clinically relevant phenomenon and increases the risk of Acute Coronary Syndrome (ACS) both in patients with stabilized coronary artery disease and in healthy individuals. This could be useful in clinical practice to help personalize and choose the most appropriate medical intervention for each patient and to develop antithrombotic drugs with a better risk\/benefit ratio than those currently used for myocardial infarction prevention.<\/p>\n\n\n\n<p>For this project, our team has developed a microfluidic platform to study thrombus formation under different flow conditions. This platform allows us to test whether platelets that undergo spontaneous platelet aggregation (SPA) are more prone to forming thrombi under experimental conditions that closely mimic in vivo physiological conditions.<\/p>\n<\/section>\n\n\n\n<div class=\"wp-block-buttons alignfull is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-d445cf74 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-background-color has-background wp-element-button\" href=\"#top\">Top<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>INNOVA: Italian network of excellence for advanced diagnosis Funded by: Italian Ministry of Health Funding period: 2023-2027 Grant number:&nbsp;PNC-E3-2022-23683266 Partners:&nbsp; The Innova project is part of the PNRR-PNC initiative, aiming to support the scientific community by interfacing with clinical and industrial entities in the Life Sciences. It focuses on translational research and innovation for major [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-741","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/pages\/741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=741"}],"version-history":[{"count":19,"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/pages\/741\/revisions"}],"predecessor-version":[{"id":1381,"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/pages\/741\/revisions\/1381"}],"wp:attachment":[{"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}