{"id":799,"date":"2024-06-13T21:47:51","date_gmt":"2024-06-13T21:47:51","guid":{"rendered":"https:\/\/www.biomech.polimi.it\/?page_id=799"},"modified":"2025-12-18T11:17:46","modified_gmt":"2025-12-18T11:17:46","slug":"cmlab_research","status":"publish","type":"page","link":"https:\/\/www.biomech.polimi.it\/?page_id=799","title":{"rendered":"CMLab_Research"},"content":{"rendered":"\n<div class=\"wp-block-buttons alignfull is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-d445cf74 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\" id=\"top\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"https:\/\/www.biomech.polimi.it\/?page_id=499\">Home<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"https:\/\/www.biomech.polimi.it\/?page_id=799\">Research<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"https:\/\/www.biomech.polimi.it\/?page_id=508\">People<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"https:\/\/www.biomech.polimi.it\/?page_id=745\">Facilities<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"http:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2025\/12\/tesi-biomech-2025-cm.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Thesis<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-color has-text-color has-link-color wp-element-button\" href=\"mailto:emiliano.votta@polimi.it\">Contacts us<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-cover alignfull is-light\" style=\"padding-top:2%;min-height:230px;aspect-ratio:unset;\"><img loading=\"lazy\" decoding=\"async\" width=\"1413\" height=\"584\" class=\"wp-block-cover__image-background wp-image-699\" alt=\"\" src=\"http:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/computational-grid-1.png\" data-object-fit=\"cover\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/computational-grid-1.png 1413w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/computational-grid-1-300x124.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/computational-grid-1-1024x423.png 1024w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/computational-grid-1-768x317.png 768w\" sizes=\"auto, (max-width: 1413px) 100vw, 1413px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-white-background-color has-background-dim-40 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-container-core-cover-is-layout-ee51f2d2 wp-block-cover-is-layout-constrained\">\n<div class=\"wp-block-group alignwide is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-5e763914 wp-block-group-is-layout-flex\" style=\"min-height:8rem\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-container-core-group-is-layout-bea02a06 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-center has-custom-color-2-color has-text-color\" style=\"margin-top:0rem;margin-bottom:1.01rem;font-size:clamp(2.071rem, 2.071rem + ((1vw - 0.2rem) * 2.98), 3.71rem);font-style:normal;font-weight:400;line-height:1;text-transform:capitalize\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#215f9a\" class=\"has-inline-color\">The Research Projects<\/mark><\/strong><\/h2>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" style=\"color:#03081e;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-02294e3b8b760221781aaa8f44d81821\" id=\"graft\"><strong>Biomechanical effects of ascending aorta grafting<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"740\" height=\"324\" src=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/nih-01.png\" alt=\"\" class=\"wp-image-863\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/nih-01.png 740w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/nih-01-300x131.png 300w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> NIH<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2023-2025<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Weill Medical College of Cornell University<\/li>\n\n\n\n<li>Yale School of Engineering &amp; Applied Science<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p style=\"padding-left:0px\">Nearly 750,000 people in the United States have thoracic aortic aneurysms (TAA), including ~150,000 with genetically triggered (\u201cgenetic\u201d) syndromic or non-syndromic aortopathies. Prosthetic graft surgery is a cornerstone of TAA therapy to eliminate the risk of aneurysm-related dissection; over 15,000 graft surgeries are performed annually. In genetic TAA patients, nearly a third of dissections  occur in the distal (arch, descending) aorta; out of these, over 50% occur after proximal graft surgery, which has been associated with &gt;2-fold increase in risk for distal aorta dissection in Marfan syndrome independent of aortic size. This effect could be due to the grafting-related loss of proximal aortic compliance, which alters the fluid-dynamics distally to the graft thus inducing adverse distal aortic remodeling and adverse clinical prognosis. Hence, adopting grafts for which compliance is tailored to compensate for patient-specific aortic stiffness should attenuate adverse aortic remodeling. These hypotheses will be tested through the analysis of magnetic resonance imaging and multi-scale numerical modeling for a prospectivelly enrolled population of patients.<\/p>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" style=\"color:#03081e;background-color:#e2f1ff;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-e49732f1781406ba3eb6993f72a0abf2\" id=\"artery\"><strong>ARTERY: <strong>Autonomous Robotics for Transcatheter dEliveRy sYstems<\/strong><\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1280\" height=\"720\" src=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/artery.png\" alt=\"\" class=\"wp-image-882\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/artery.png 1280w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/artery-300x169.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/artery-1024x576.png 1024w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/artery-768x432.png 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> H2020-ICT-2018-20<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2021-2024<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;101017140<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Istituto di Biorobotica, Scuola Superiore Sant\u2019Anna<\/li>\n\n\n\n<li>KU Leuven<\/li>\n\n\n\n<li>IRCCS San Raffaele Hospital<\/li>\n\n\n\n<li>SwissVortex<\/li>\n\n\n\n<li>Artiness<\/li>\n\n\n\n<li>FBGS<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p>Cardiovascular diseases are the single most common cause of death in Europe and worldwide. Minimally invasive catheter-based approaches are gaining in importance as they extend treatment to patients with high surgical peri-operative risks. Today, catheter-based treatment comes with steep learning curves, poor ergonomics and exposure to damaging radiation.<\/p>\n\n\n\n<p>ARTERY offers a radiation-free approach based on shared-autonomy robotic catheters, with increased user engagement and easy interaction. The fusion of the information yielded by echocardiography, optical and electromagnetic sensing techniques will provide a superior view upon the cardiovascular space. Fluidic actuation paired with artificial intelligence will be the pillars motors of the next generation of robotic catheters that autonomously find their way towards the target site. Through a fully immersive augmented reality interface, the operator will monitor the intravascular route of the catheter with no need for radiation-based imaging. Once into the heart, the operator will be able to navigate the intracardiac domain as if being teleported right inside the patient\u2019s anatomy and will define the catheter target pose by simple gestures into the holographic representation. Artificial intelligence algorithms will automatically translate this input into the set of actions to be performed by the actuators. Variable-autonomy schemes allow the interventionist to take over control at any instant.<\/p>\n\n\n\n<p>ARTERY will showcase this new paradigm on mitral valve repair and left appendage closure, two complex yet critical life-saving interventions. Clinicians and company partners are ready to take over the technology developed in ARTERY and translate it to the clinic right after the project.<\/p>\n\n\n\n<p>In ARTERY, the expertise of our group in computational modeling, mixed reality and AI are merged with the expertise of the&nbsp;<a href=\"http:\/\/nearlab.polimi.it\/medical\/\" target=\"_blank\" rel=\"noreferrer noopener\">Medical Robotics Section of NearLab<\/a>&nbsp;on surgical robotics and human-robot interaction.&nbsp;<\/p>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" id=\"merlin\" style=\"color:#03081e;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-9ca1c66a3e9ce199f387a734138f0c1b\" id=\"merlin\"><strong>MixEd ReaLIty in Neurosurgery &#8211; MERLIN: development of a new neuronavigation platform based on mixed reality<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1473\" height=\"1612\" src=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/merlin.png\" alt=\"\" class=\"wp-image-917\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/merlin.png 1473w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/merlin-274x300.png 274w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/merlin-936x1024.png 936w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/merlin-768x840.png 768w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/merlin-1404x1536.png 1404w\" sizes=\"auto, (max-width: 1473px) 100vw, 1473px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> MIUR &#8211; Italian Ministry of University and Research, PRIN 2022 Call<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2023-2025<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;202225T8S7<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p>Anatomical understanding and spatial orientation are paramount to the success of neurosurgical procedures and still represent a cognitive challenge for neurosurgeons. Thorough pre-procedural planning is hence required, and the possibility to effectively leverage the planned scenario in the operating room (OR) as intra-procedural support would make procedures safer and faster. The MERLIN project aims to developing an effective and feasible technological solution to support neurosurgeons in the pre-operative planning phase, allowing them for the intuitive navigation of the patient&#8217;s anatomy, and intra-operatively, by providing them with a virtual guide co-registered on the patient. <\/p>\n<\/div>\n<\/div>\n\n\n\n<p style=\"padding-left:0px\">To this aim, the project will integrate four technologies: i) artificial intelligence for the automatic segmentation of pre-operative medical imaging; ii) mixed reality to intuitively navigate the image-based 3D anatomical model, to plan the procedure, and to visualize the planned scenario in the OR; iii) cloud computing to allow for fast reconstruction of the anatomical models and deplyment of the mixed reality app from GDPR-compliant platforms; iv) markerless hologram-to-patient registration algorithms allowing for precision without the need for bulky equipment or for cumbersome registration procedures. Our solution will be developed and tested in vitro on physical phantoms, and its usability will be tested in the OR.<\/p>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" id=\"merlin\" style=\"color:#03081e;background-color:#e2f1ff;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-baf66ef0d64347f1321627f429503637\" id=\"futuro\"><strong>FUTURO: Focused Ultrasound Surgery enabled by Robotics and Simulation<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"523\" height=\"540\" src=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/futuro-project.png\" alt=\"\" class=\"wp-image-1185\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/futuro-project.png 523w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/futuro-project-291x300.png 291w\" sizes=\"auto, (max-width: 523px) 100vw, 523px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> MIUR &#8211; Italian Ministry of University and Research, PRIN 2022 Call<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2023-2025<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;2022342MEF<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Scuola Superiore Sant\u2019Anna, PISA, Italy<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p>Focused Ultrasound (FUS) Surgery is emerging as an early-stage, non-invasive, scarless technology which offers a disruptive, game-changing alternative to surgery, capable of complementing radiation therapy, drug delivery, and immunotherapy. FUS technology allows for delivering large mechanical energy into deep tissues, without any harm for the tissues on the path, enables a plethora of therapeutic actions: tissue ablation\/destruction, radiosensitization, vascular permeability, etc. The aim of FUtuRo is to boost the use of this novel solution for non-invasive surgery thanks to the incorporation of robotic guidance, image analysis, tissue modeling and extended reality.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" id=\"merlin\" style=\"color:#03081e;background-color:#ffffff;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-7ffb0a70a6a65ca9a3fce0dd6993dd00\" id=\"anthem\"><strong>ANTHEM: AdvaNced Technologies for Human-centrEd Medicine<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"360\" height=\"360\" src=\"http:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon.png\" alt=\"\" class=\"wp-image-1049\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon.png 360w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon-300x300.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon-150x150.png 150w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> MIUR &#8211; Italian Ministry of University and Research, PNC Initiative<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2022-2026<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;PNC0000003<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Humanitas University <\/li>\n\n\n\n<li>Universit\u00e0 del Salento <\/li>\n\n\n\n<li>Chiesi Farmaceutici <\/li>\n\n\n\n<li>ab medica<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p>ANTHEM aims at developing of Advanced Imaging Systems to Enhance Patient Stratification by Applying AI-Based Diagnostic Tools to Technologies Already Used in Clinical Practice as CT, MRI and Photon Counting.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" id=\"merlin\" style=\"color:#03081e;background-color:#e2f1ff;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-25d0da87813a0cd88534188c0b0601ab\" id=\"concerto\"><strong>CONCERTO: Computational mOdelliNg of myoCardial pERfusion to improve ouTcome prediction based on cOronary artery stenosis and atherosclerotic plaque burden assessment by computed tomography<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"360\" height=\"360\" src=\"http:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon.png\" alt=\"\" class=\"wp-image-1049\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon.png 360w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon-300x300.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon-150x150.png 150w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> Italian Ministry of Health<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2023-2025<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;PNRR-POC-2022-12376500<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IRCCS Centro Cardiologico Monzino, Milano, Italy <\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p>Coronary CT is an important diagnostic tool for coronary atheromatous disease, the main cause of myocardial infarction. CT is the only non-invasive examination that allows cardiologists to visualize the coronary arteries, identifying plaques that cause narrowing (stenosis), which reduces blood flow through these vessels. The CONCERTO project aims at applying computational models to myocardial perfusion to predict Myocadial Blood Flow (MBF) avoiding the stress protocol and potential side effects while reducing radiation exposure.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" id=\"merlin\" style=\"color:#03081e;background-color:#ffffff;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-b23dccfdcec2e19a2790751abf4eae76\" id=\"ai-corps\"><strong>AI-Corps: Trustworthy, integrated <strong>A<\/strong>rtificial <strong>I<\/strong>ntelligence tools for predicting high-risk <strong>COR<\/strong>on<strong>a<\/strong>ry <strong>P<\/strong>laque<strong>S<\/strong><\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"360\" height=\"360\" src=\"http:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon.png\" alt=\"\" class=\"wp-image-1049\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon.png 360w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon-300x300.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon-150x150.png 150w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> Fondazione Regionale Ricerca Biomedica<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2023-2026<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;FRRB 3432721<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IRCCS Centro Cardiologico Monzino<\/li>\n\n\n\n<li>IRCCS San Raffaele Scientific Institute<\/li>\n\n\n\n<li>IRCCS Fondazione Policlinico San Matteo <\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p>Coronary artery disease (CAD) is among the leading cause of death and disability. Identification of patients at high risk of cardiovascular events is pivotal. However, current risk stratification based on imaging and known biomarkers is suboptimal. The objective of this proposal is to develop a multicriteria decision model for non-invasive assessment of vulnerable atherosclerotic patients and to evaluate its ability to predict the occurrence of an adverse event in intermediate-to-high risk patients with suspected or known CAD, using AI-based coronary segmentation, radiomics and advanced numerical modeling.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<section class=\"wp-block-group alignfull has-text-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-b691706e wp-block-group-is-layout-constrained\" id=\"merlin\" style=\"color:#03081e;background-color:#e2f1ff;margin-top:0px;padding-top:4.01rem;padding-right:1rem;padding-bottom:5.5rem;padding-left:1rem;font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.464), 1.13rem);font-style:normal;font-weight:400;line-height:1.4\">\n<p class=\"has-text-align-center has-custom-color-2-color has-text-color has-link-color has-large-font-size wp-elements-cc289c8661976a56e054642cd7b2312c\" id=\"calhubria\"><strong>Cal.Hub.Ria: CALabria HUB per Ricerca Innovativa ed Avanzata<\/strong><\/p>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:90px;flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"360\" height=\"360\" src=\"http:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon.png\" alt=\"\" class=\"wp-image-1049\" style=\"width:500px;height:auto\" srcset=\"https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon.png 360w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon-300x300.png 300w, https:\/\/www.biomech.polimi.it\/wp-content\/uploads\/2024\/06\/soon-150x150.png 150w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:5%;flex-basis:80%\">\n<p><strong>Funded by:<\/strong> Italian Ministry of Health<\/p>\n\n\n\n<p><strong>Funding period<\/strong>: 2023-2026<\/p>\n\n\n\n<p><strong>Grant number:<\/strong>&nbsp;POS T4-AN-09<\/p>\n\n\n\n<p><strong>Partners:<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fondazione IRCCS Istituto Neurologico &#8220;Carlo Besta&#8221;<\/li>\n\n\n\n<li>IRCCS Centro Cardiologico Monzino<\/li>\n\n\n\n<li>IRCCS Istituto Europeo di Oncologia<\/li>\n\n\n\n<li>IRCCS Policlinico San Donato<\/li>\n\n\n\n<li>Universit\u00e0 della Calabria<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p>Cal.Hub.Ria targets a broad range of clinically-oriented goals through interdisciplinary activities. We will contribute to two goals in particular: i) developing a computational federated platform for orphan and rare diseases to be used in the framework of a joint research platform; ii) identifying new early markers of aortopathy progression in patients affected by Marfan syndrome through patient-specific biomechanical and epi-genetic analyses.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<div class=\"wp-block-buttons alignfull is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-d445cf74 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-custom-color-2-background-color has-text-color has-background has-link-color wp-element-button\" href=\"#top\" style=\"color:#ffffff\">Top<\/a><\/div>\n<\/div>\n\n\n\n<p style=\"padding-left:0px\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biomechanical effects of ascending aorta grafting Funded by: NIH Funding period: 2023-2025 Grant number:&nbsp; Partners:&nbsp; Nearly 750,000 people in the United States have thoracic aortic aneurysms (TAA), including ~150,000 with genetically triggered (\u201cgenetic\u201d) syndromic or non-syndromic aortopathies. Prosthetic graft surgery is a cornerstone of TAA therapy to eliminate the risk of aneurysm-related dissection; over 15,000 [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-799","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/pages\/799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=799"}],"version-history":[{"count":46,"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/pages\/799\/revisions"}],"predecessor-version":[{"id":1506,"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=\/wp\/v2\/pages\/799\/revisions\/1506"}],"wp:attachment":[{"href":"https:\/\/www.biomech.polimi.it\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}