Platelet Function and Thrombogenicity
Our research is devoted to the analysis of the thrombogenic potential of blood-contacting medical devices, with a specific emphasis on shear-mediated platelet activation. We also aim to develop point-of-care systems for bedside assessment of platelet function, enabling effective and efficient drug management to prevent thromboembolic complications.
Thrombogenicity of blood contacting medical devices
We integrate advanced computational and experimental techniques for optimizing the thrombogenic performance of cardiovascular devices.
Platelet function testing
We develop point-of-care platelet aggregation systems by integrating microfluidics, electronics and impedance measurements
In vitro vascular models
We design microfluidic vessel-on-a-chip platforms to study vascular pathologies, specifically focusing on interactions between platelets and endothelium.
Our Projects
In vitro thrombogenicity testing
We use flow loop circuits replicating the clinical use of cardiovascular devices to assess their thrombogenicity with the platelet activity state (PAS) assay, which measures real-time thrombin production rates of activated platelets.
Platelet-on-chip technologies
We develop lab-on-a-chip systems to facilitate platelet manipulation, including on-chip platelet separation from whole blood and platelet cell counting.
Our Projects