CB Lab

Laboratorary of Computational Biomechanics

mimiclab

CB Lab develops cutting edge computational models for the analysis of tissue, organs, and devices, with an emphasis on cardiovascular applications.

Finite element modeling allows for the detailed quantification of the structural mechanics of tissues and organs, as well as for the impact of implantable devices and procedures on the stresses acting on the relevant native structures. Finite volume modeling allows for quantifying the fluid dynamics within blood vessels, cardiac chambers and blood-processing devices. When fed with information derived from medical images, these techniques allow for patient-specific simulations that can allow for the deeper and underwise unfeasible understanding of pathological conditions, so to improve diagnosis and prognosis, as well as to predict the effect of surgical and interventional solutions.

Moreover, CB Lab is involved in the activities of other Labs of the Group (Mimic Lab, Th Lab, μBs Lab) by supporting the design of microfluidic devices and artificial organs, as well as by providing numerical analyses that complement in vitro experiments. 

 

 

Research interests

Through the years, we have been developing a broad spectrum of activities in the field of cardiovascular mechanics, which all share a strong translational interest:

Image-based Patient-specific Modeling

  • Analysis of biomechanical derangements associated to pathological conditions in large vessels, heart valves and heart chambers through anatomically detailed models
  • Prediction of the biomechanical effect of surgical or interventional procedures on a patient-specific basis
  • Quantification of in vivo tissue strains directly from medical images
  • Quantification of in vivo blood fluid dynamics based on 4Dflow images

Multi-scale Modeling of Organs

  • Derivation of mechanical stimuli on valvilar interstitial cells starting from finite element simulations at the organ length-scale

Analysis of Blood-Processing devices

  • Quantification of the performance of left ventricular assist devices (LVADs), blood pumps and oxygenators, as well as of the associated risk of blood damage
  • Assessment of the risk of shear-mediates platelet activation

Holography for Augmented Reality

  • 4D visualization of volumetric datasets from medical imaging
  • Developing tools to support surgical and interventional planning

Team

Faculties  

Alberto Redaelli, PhD

Full Professor
Computational Fluid Dynamics

Tel.: +39-02-2399-3375
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Emiliano Votta, PhD

Associate Professor
Computational Structural Mechanics

Tel.: +39-02-2399-3461
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Giuseppe Passoni, PhD

Associate Professor
Computational Fluid Dynamics

Tel.: +39-02-2399-6232
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Silvia Bozzi, PhD

Associate Professor
Computational Fluid Dynamics

Tel.: +39-02-2399-4146
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Postdocs  

Alessandro Caimi, PhD

Patient-specific Finite Element Modelin

Tel.: +39-02-2399-3370
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PhD Students  

Maria Chiara Palumbo, MSc

PhD Candidate
4Dflow-based in vivo Fluid Dynamics

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Simone Saitta, MSc

PhD Candidate
4Dflow-based in vivo Fluid Dynamics

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Master Students  

  Alberto Scolari, BSc

  Giovanna Nitidi, BSc

  Chiara Gussago, BSc 

  Federica Gambogi, BSc 

  Giada Suriano, BSc 

  Lisa Parolari, BSc 

  Marta Alva Zanetti, BSc 

  Gregorio Contarini, BSc 

  Valentina Scarponi, BSc 

  Anisia Lauditi, BSc 

  Alessandro Lanaro, BSc 

  Alexa Bicelli, BSc 

  Marta Anghileri, BSc 

  Nadia Brambilla, BSc 

  Silvia Sechi, BSc 

  Ida Giulivo, BSc 

  Giulio D'Errico, BSc 

  Giulia Cortinovis, BSc 

  Davide Piatti, BSc 

  Gregory Zocchi, BSc 

   Laura Strambi, BSc

  Agnese Mantoan, BSc

  Chiara Dazzi, BSc

  Alessio Amicone, BSc

Alumni

2020

Serena Mognoni, Msc

Margherita Moroni, Msc

Guido Nannini, Msc

Mattia Lupacchini, Msc

2019

Lorenzo Alloni, Msc

Chiara Trenti, Msc

Marcello Arcangeli, Msc

Greta Locatelli, Msc

Chiara Manini, Msc

Monica Emendi, Msc

Andrea Boraschi, Msc

Jacopo Monti, Msc

Fabio Lucon, Msc

Matteo Frigelli, Msc

Matteo Pasquali, Msc

Elena Corna, Msc

Antonio Crescenzo, Msc

Francesca Comi, Msc

Alessandro Bastianoni, Msc

2018

Sabrina Ibba, Msc

Irene Torrisi, Msc

Giulia Girola, Msc

Silvia Ciuffreda, Msc

Ilaria Urciuoli, Msc

Stefano Tagliabue, Msc

Valentina Messina, Msc

Laura Marelli, Msc

Massimiliano Bugana, Msc

Ilaria Pizzaballa, Msc

Antony Pranzetti, Msc

Simone Saitta, Msc

2017

Luca Meloni, Msc

Andreea Eva, Msc

Masoud Meskin, Msc

Tommaso Cazzato, Msc

Federica Colombo, Msc

Silvia Pozzi, Msc

Selene Pirola, Msc

Martina Gava, Msc

Angela Aversa, Msc

Eleonora Careddu, Msc

2016

Elena Bonini, Msc

Elisa Stoppani, Msc

Marco Sabbatini, Msc

Giovanni Rossini, Msc

Giulia Conca, Msc

Francesca Ghidelli, Msc

Silvia Vago, Msc

Maria Chiara Palumbo, Msc

Agostino Di Bello, Msc

Stefania Tirelli, Msc

Giulia Signorini, Msc

Rachele De Ponti, Msc

Marco Vidotto, Msc

Chiara Baggi, Msc

2015

Herman Fruner, Msc

Michela Cagna, Msc

Silvia Rossi, Msc

Viviana Mancini, Msc

Stefano Speranza, Msc

Roberta Testa, Msc

Germano Infante, Msc

Elisabetta Tedaldi, Msc

Chiara Montanari, Msc

Martina Patelli, Msc

Flavio Bellacosa Marotti, Msc

Luca Scotti, Msc

Pietro Galella, Msc

Mattia Ronzoni, Msc

Mattia Vitali, Msc

Federico Canè, Msc

Anna Senesi, Msc

Marica Presicce, Msc

Matteo Selmi, Msc

Lara Soggiu, Msc

2014

Rosamaria Tricarico, Msc

Filippo Piatti, PhD

Omar Antonio Pappalardo, PhD

Valentina Elia, Msc

Giulia Campo, Msc

Matteo Manessi, Msc

Benedetto D'Antico, Msc

Simone Mazzola, Msc

Matteo Fazio, Msc

Francesca Bonizzoni, Msc

Giacomo Mazzoletti, Msc

Daniela Piloni, Msc

Laura Spreafico, Msc

Stefano Derobertis, Msc

Francesco Calivà, Msc

 

  

Publications

 

Publications

  1. Pluchinotta FR, Sturla F, Caimi A, Giugno L, Chessa M, Giamberti A, Votta E, Redaelli A, Carminati M. 3-Dimensional personalized planning for transcatheter pulmonary valve implantation in a dysfunctional right ventricular outflow tract. Int J Cardiol. 2019 Dec 6. pii: S0167-5273(19)34925-3. doi: 10.1016/j.ijcard.2019.12.006.

  2. Pappone C, Mecarocci V, Manguso F, Ciconte G, Vicedomini G, Sturla F, Votta E, Mazza B, Pozzi P, Borrelli V, Anastasia L, Micaglio E, Locati E, Monasky M, Lombardi M, Calovic Z, Santinelli V. New Electro-Mechanical Substrate Abnormalities in High-Risk Patients with Brugada Syndrome. Heart Rhythm. 2019 Nov 19. pii: S1547-5271(19)31031-8. doi: 0.1016/j.hrthm.2019.11.019.

  3.  Butera G, Sturla F, Pluchinotta FR, Caimi A, Carminati M. Holographic Augmented Reality and 3D Printing for Advanced Planning of Sinus Venosus ASD/Partial Anomalous Pulmonary Venous Return Percutaneous Management. JACC Cardiovasc Interv. 2019 May 11. pii: S1936-8798(19)30751-4. doi: 10.1016/j.jcin.2019.03.020. [Epub ahead of print]

  4. Dimasi A, Piloni D, Spreafico L, Votta E, Vismara R, Fiore G, Meskin M, Fusini L, Muratori M, Montorsi P, Pepi M, Redaelli A. Fluid-structure interaction and in vitro analysis of a real bileaflet mitral prosthetic valve to gain insight into Doppler-silent thrombosis. J Biomech Eng. 2019 May 4. doi: 10.1115/1.4043664. [Epub ahead of print]

  5. Meskin M, Dimasi A, Votta E, Jaworek M, Fusini L, Muratori M, Montorsi P, Zappa E, Epifani I, Pepi M, Redaelli A. A Novel Multiparametric Score for the Detection and Grading of Prosthetic Mitral Valve Obstruction in Cases With Different Disc Motion Abnormalities. Ultrasound Med Biol. 2019 May 4. pii: S0301-5629(19)30126-7. doi: 10.1016/j.ultrasmedbio.2019.03.011. [Epub ahead of print]

  6. Saitta S, Pirola S, Piatti F, Votta E, Lucherini F, Pluchinotta F, Carminati M, Lombardi M, Geppert C, Cuomo F, Figueroa CA, Xu XY, Redaelli A. Evaluation of 4D flow MRI-based non-invasive pressure assessment in aortic coarctations. J Biomech. 2019 Sep 20;94:13-21. doi: 10.1016/j.jbiomech.2019.07.004.

  7. Della Corte A, Michelena HI, Citarella A, Votta E, Piatti F, Lo Presti F, Ashurov R, Cipollaro M, Forte A. Risk Stratification in Bicuspid Aortic Valve Aortopathy: Emerging Evidence and Future Perspectives. Curr Probl Cardiol. 2019 Jun 21. pii: S0146-2806(19)30101-X. doi: 10.1016/j.cpcardiol.2019.06.002.

  8. Canè F, Selmi M, De Santis G, Redaelli A, Segers P, Degroote J. Mixed impact of torsion on LV hemodynamics: A CFD study based on the Chimera technique. Comput Biol Med. 2019 Sep;112:103363. doi: 10.1016/j.compbiomed.2019.103363.

  9. Rong LQ, Palumbo MC, Rahouma M, Meineri M, Arguelles GR, Kim J, Lau C, Devereux RB, Pryor KO, Girardi LN, Redaelli A, Gaudino MFL, Weinsaft JW. Immediate Impact of Prosthetic Graft Replacement of the Ascending Aorta on Circumferential Strain in the Descending Aorta. Eur J Vasc Endovasc Surg. 2019 Oct;58(4):521-528. doi: 10.1016/j.ejvs.2019.05.003.

  10. Tasca G, Selmi M, Riva B, Lobiati E, Gamba A, Redaelli A, Votta E. Aortic Root Dynamics in Sleeve Aortic Sparing Procedure: Echocardiographic and Computational Studies. Semin Thorac Cardiovasc Surg. 2019 Jul 26. pii: S1043-0679(19)30204-7. doi: 10.1053/j.semtcvs.2019.07.010. 
  11. Selmi M, Chiu WC, Chivukula VK, Melisurgo G, Beckman JA, Mahr C, Aliseda A, Votta E, Redaelli A, Slepian MJ, Bluestein D, Pappalardo F, Consolo F. Blood damage in Left Ventricular Assist Devices: Pump thrombosis or system thrombosis? Int J Artif Organs. 2018 Oct 24:391398818806162. doi: 10.1177/0391398818806162.

  12. Gaudino M, Piatti F, Lau C, Sturla F, Weinsaft JW, Weltert L, Votta E, Galea N, Chirichilli I, Di Franco A, Francone M, Catalano C, Redaelli A, Girardi LN, De Paulis R. Aortic flow after valve sparing root replacement with or without neosinuses reconstruction. J Thorac Cardiovasc Surg. 2018 Jul 27. pii: S0022-5223(18)32026-9. doi: 10.1016/j.jtcvs.2018.06.094.

  13. Caimi A, Sturla F, Pluchinotta FR, Giugno L, Secchi F, Votta E, Carminati M, Redaelli A. Prediction of stenting related adverse events through patient-specific finite element modelling. J Biomech. 2018 Oct 5;79:135-146. doi: 10.1016/j.jbiomech.2018.08.006.

  14. Gaidulis G, Votta E, Selmi M, Aidietienė S, Aidietis A, Kačianauskas R. Numerical simulation of transapical off-pump mitral valve repair with neochordae implantation. Technol Health Care. 2018;26(S2):635-645. doi: 10.3233/THC-182510.

  15. Galea N, Piatti F, Sturla F, Weinsaft JW, Lau C, Chirichilli I, Carbone I, Votta E, Catalano C, De Paulis R, Girardi LN, Redaelli A, Gaudino M; Cornell International Consortium for Aortic Surgery (CICAS). Novel insights by 4D Flow imaging on aortic flow physiology after valve-sparing root replacement with or without neosinuses. Interact Cardiovasc Thorac Surg. 2018 Jun 1;26(6):957-964. doi: 10.1093/icvts/ivx431.

  16. Piatti F, Palumbo MC, Consolo F, Pluchinotta F, Greiser A, Sturla F, Votta E, Siryk SV, Vismara R, Fiore GB, Lombardi M, Redaelli A. Experimental quantification of the fluid dynamics in blood-processing devices through 4D-flow imaging: A pilot study on a real oxygenator/heat-exchanger module. J Biomech. 2018 Feb 8;68:14-23. doi: 10.1016/j.jbiomech.2017.12.014.

  17. Tedaldi E, Montanari C, Aycock KI, Sturla F, Redaelli A, Manning KB. An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC. Med Eng Phys. 2018 Apr;54:44-55. doi: 10.1016/j.medengphy.2018.02.003.

  18. Caimi A, Sturla F, Good B, Vidotto M, De Ponti R, Piatti F, Manning KB, Redaelli A. Toward the Virtual Benchmarking of Pneumatic Ventricular Assist Devices: Application of a Novel Fluid-Structure Interaction-Based Strategy to the Penn State 12 cc Device. J Biomech Eng. 2017 Aug 1;139(8). doi: 10.1115/1.4036936.

  19. Pappalardo OA, Sturla F, Onorati F, Puppini G, Selmi M, Luciani GB, Faggian G, Redaelli A, Votta E. Mass-spring models for the simulation of mitral valve function: Looking for a trade-off between reliability and time-efficiency. Med Eng Phys. 2017 Sep;47:93-104. doi: 10.1016/j.medengphy.2017.07.001.

  20. Piatti F, Sturla F, Bissell MM, Pirola S, Lombardi M, Nesteruk I, Della Corte A, Redaelli ACL, Votta E. 4D Flow Analysis of BAV-Related Fluid-Dynamic Alterations: Evidences of Wall Shear Stress Alterations in Absence of Clinically-Relevant Aortic Anatomical Remodeling. Front Physiol. 2017 Jun 26;8:441. doi: 10.3389/fphys.2017.00441. eCollection 2017.

  21. Piatti F, Pirola S, Bissell M, Nesteruk I, Sturla F, Della Corte A, Redaelli A, Votta E. Towards the improved quantification of in vivo abnormal wall shear stresses in BAV-affected patients from 4D-flow imaging: Benchmarking and application to real data. J Biomech. 2017 Jan 4;50:93-101. doi: 10.1016/j.jbiomech.2016.11.044. Epub 2016 Nov 11.

  22. Sturla F, Onorati F, Puppini G, Pappalardo OA, Selmi M, Votta E, Faggian G, Redaelli A. Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging. J Thorac Dis. 2017 Apr;9(Suppl 4):S225-S238. doi: 10.21037/jtd.2017.03.84.

  23. Sturla F, Vismara R, Jaworek M, Votta E, Romitelli P, Pappalardo OA, Lucherini F, Antona C, Fiore GB, Redaelli A. In vitro and in silico approaches to quantify the effects of the Mitraclip® system on mitral valve function. J Biomech. 2017 Jan 4;50:83-92. doi: 10.1016/j.jbiomech.2016.11.013.

  24. Tasca G, Selmi M, Votta E, Redaelli P, Sturla F, Redaelli A, Gamba A. Aortic Root Biomechanics After Sleeve and David Sparing Techniques: A Finite Element Analysis. Ann Thorac Surg. 2017 May;103(5):1451-1459. doi: 10.1016/j.athoracsur.2016.08.003.

  25. Votta E, Presicce M, Della Corte A, Dellegrottaglie S, Bancone C, Sturla F, Redaelli A. A novel approach to the quantification of aortic root in vivo structural mechanics. Int J Numer Method Biomed Eng. 2017 Sep;33(9). doi: 10.1002/cnm.2849

  26. Sturla F, Ronzoni M, Vitali M, Dimasi A, Vismara R, Preston-Maher G, Burriesci G, Votta E, Redaelli A. Impact of different aortic valve calcification patterns on the outcome of transcatheter aortic valve implantation: A finite element study. J Biomech. 2016 Aug 16;49(12):2520-30. doi: 10.1016/j.jbiomech.2016.03.036.

  27. Sturla F, Votta E, Onorati F, Pechlivanidis K, Pappalardo OA, Gottin L, Milano AD, Puppini G, Redaelli A, Faggian G. Biomechanical drawbacks of different techniques of mitral neochordal implantation: When an apparently optimal repair can fail. J Thorac Cardiovasc Surg. 2015 Nov;150(5):1303-1312. DOI: 10.1016/j.jtcvs.2015.07.014.

  28. Piatti F, Sturla F, Marom G, Sheriff J, Claiborne TE, Slepian MJ, Redaelli A, Bluestein D. Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach. J Biomech. 2015 Oct;48(13):3650-8 DOI: 10.1016/j.jbiomech.2015.08.009.

  29. Sturla F, Redaelli A, Puppini G, Onorati F, Faggian G, Votta E. Functional and Biomechanical Effects of the Edge-to-Edge Repair in the Setting of Mitral Regurgitation: Consolidated Knowledge and Novel Tools to Gain Insight into Its Percutaneous Implementation. Cardiovasc Eng Technol. 2015 Jun;6(2):117-40 DOI: 10.1007/s13239-014-0208-4.

  30.  Pelosi A, Sheriff J, Stevanella M, Fiore GB, Bluestein D, Redaelli A. Computational evaluation of the thrombogenic potential of a hollow-fiber oxygenator with integrated heat exchanger during extracorporeal circulation. Biomech Model Mechanobiol. 2014 Apr;13(2):349-61.

  31. Sturla F, Onorati F, Votta E, Pechlivanidis K, Stevanella M, Milano AD, Puppini G, Mazzucco A, Redaelli A, Faggian G. Is it possible to assess the best mitral valve repair in the individual patient? Preliminary results of a finite element study from magnetic resonance imaging data. J Thorac Cardiovasc Surg. 2014 Sep;148(3):1025-34; discussion 1034.

  32. Protti A, Votta E, Gattinoni L. Which is the most important strain in the pathogenesis of ventilator-induced lung injury: dynamic or static? Curr Opin Crit Care. 2014 Feb;20(1):33-8.

  33. Pelosi A, Sheriff J, Stevanella M, Fiore GB, Bluestein D, Redaelli A. Computational evaluation of the thrombogenic potential of a hollow-fiber oxygenator with integrated heat exchanger during extracorporeal circulation. Biomech Model Mechanobiol. 2014 Apr;13(2):349-61. doi: 10.1007/s10237-012-0445-0.
  34. Votta E, Le TB, Stevanella M, Fusini L, Caiani EG, Redaelli A, Sotiropoulos F. Toward patient-specific simulations of cardiac valves: state-of-the-art and future directions. J Biomech. 2013 Jan 18;46(2):217-28.

  35. Sturla F, Votta E, Stevanella M, Conti CA, Redaelli A. Impact of modeling fluid-structure interaction in the computational analysis of aortic root biomechanics. Med Eng Phys. 2013 Dec;35(12):1721-30.

  36. De Lorenzo D, De Momi E, Conti L, Votta E, Riva M, Fava E, Bello L, Ferrigno G. Intraoperative forces and moments analysis on patient head clamp during awake brain surgery. Med Biol Eng Comput. 2013 Mar;51(3):331-41.

  37. Protti A, Andreis DT, Monti M, Santini A, Sparacino CC, Langer T, Votta E, Gatti S, Lombardi L, Leopardi O, Masson S, Cressoni M, Gattinoni L. Lung stress and strain during mechanical ventilation: any difference between statics and dynamics? Crit Care Med. 2013 Apr;41(4):1046-55.

  38. Della Corte A, Bancone C, Del Viscovo L, Conti CA, Votta E, Scognamiglio G, Covino FE, Redaelli A, Cotrufo M. Restricted cusp motion in right-left type of bicuspidaorticvalves: A new risk marker for aortopathy. J Thorac Cardiovasc Surg. 2012; 144(2):360-369.

  39. Dimasi A, Cattarinuzzi E, Stevanella M, Conti CA, Votta E, Maffessanti F, Ingels NB Jr., Redaelli A. Influence of Mitral Valve Anterior Leaflet in vivo Shape on Left Ventricular Ejection. Cardiovasc Eng Technol 2012; 3(4):388-401.

  40. Consolo F, Bariani C, Mantalaris A, Montevecchi F, Redaelli A, Morbiducci U. Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells. Biomech Model Mechanobiol. 2012; 11(1-2):261-77.
  41. Morbiducci U, Ponzini R, Rizzo G, Biancolini ME, Iannaccone F, Gallo D, Redaelli A. Synthetic dataset generation for the analysis and the evaluation of image-based hemodynamics of the human aorta. Med Biol Eng Comput 2012; 50:145-54.

  42. Votta E, Paroni L, Conti CA, Pelosi A, Mangini A, D'Alesio P, Vismara R, Antona C, Redaelli A. Aortic valve repair via neo-chordae technique: mechanistic insight through numerical modelling. Ann Biomed Eng. 2012; 40(5):1039-51.  

  

Prizes and Honors

 

Journal Awards

M. Stevanella, F. Maffessanti, C.A. Conti, E. Votta, A. Arnoldi, M. Lombardi, O. Parodi, E.G. Caiani, A. Redaelli
“Mitral Valve Patient-Specific Finite Element Modeling from Cardiac MRI: Application to an Annuloplasty Procedure” 
2017 CVET Most Cited Article Award, jointly awarded by the Biomedical Engineering Society and Springer Nature, for being the most cited article from papers published in Cardiovascular Engineering Technologies (CVET) since its inception in March 2010. 

E. Votta, T.B. Le, M. Stevanella, L. Fusini, E.G. Caiani, A. Redaelli, F. Sotiropoulos
"Toward patient-specific simulations of cardiac valves: state-of-the-art and future directions"  
Elsevier Highly Cited Research Certificate for being among the top five most cited manuscripts in years 2014/2015 up to June, 2016.

 

Conference Awards

S. Pirola, F. Piatti, F. Sturla, E. Votta, I. Nesteruk, M. Lombardi, A. Della Corte, M. Bissell, A. Redaelli, E. G. Caiani
"Phase Contrast MRI: Development of a User-Friendly Platform for Fast Automated Segmentation and Fluid-Dynamic Post-Processing"
Rosanna Degani Young Investigators' Award (Semi-finalist), 42nd Annual Conference, Computing in Cardiology (CINC), September 6-9, 2015, Nice, France

A. Caimi, F. Cané, A. Senesi, A. Dimasi, F. Sturla, K.B. Manning, A. Redaelli
"CFD Characterization of a Pediatric Ventricular Assist Device through a Moving Boundary Approach" 
Award in the 2014 International CAE conference - Poster Presentation - Pacengo del Garda (Verona), Italy

F. Piatti, F. Sturla, T.E. Claiborne, D. Bluestein, A. Redaelli
"A fluid-structure approach to optimize the thrombogenic potential of artificial heart valves"
Award in the 2014 International CAE conference - Poster Presentation - Pacengo del Garda (Verona), Italy

F. Piatti, M. Selmi, A. Pelosi, T.E. Claiborne, D. Bluestein, A. Redaelli
"CFD characterization and thrombogenicity analysis of a prototypal polymeric aortic valve"
Award in the 2013 International CAE conference - Poster Presentation - Pacengo del Garda (Verona), Italy

M. Stevanella, F. Sturla, C.A. Conti, E. Votta, A. Della Corte, A. Redaelli
"Healty and BAV-affected aortic root dynamics: Fluid Structure Interaction simulations from MRI-based 3D models"
Award in the 2012 International CAE conference - Poster Presentation - Pacengo del Garda (Verona), Italy 

F. Consolo, M. Caronna, F.M. Montevecchi, G.B. Fiore, A. Redaelli
"A CFD computational model for the optimization of transport phenomena in a rotating hollow fiber bioreactor for artificial liver"
2nd place award in the PhD Student Competition - Poster Presentation in the Biofluids and Imaging Category of the “2008 Summer Bioengineering Conference of the American Society of Mechanical Engineering“, Marco Island, Florida

E. Votta, A. Arnoldi, M. Stevanella, F. Veronesi, G. Tamborini, F. Alamanni, E.G. Caiani, A. Redaelli
"From real-time 3D echocardiography to mitral valve finite element analysis: a novel modeling approach"
Rosanna Degani Young Investigator Award at the 2008 Computers in Cardiology Conference, Bologna, Italy

M. Soncini, A. Redaelli, E. Votta, A. Sormani
"3-D computational models for the simulation of the suture stress after mitral valve edge-to-edge repair"
Best poster award in the session of Cardiovascular Mechanics of the 2001 Bioengineering Conference of the American Society of Mechanical Engineering, Snowbird, Utah

 

MSc and PhD Thesis Awards

Selene Pirola
"Valutazione clinica mediante 4D-flow MRI delle alterazioni fluidodinamiche indotte da bicuspidia valvolare aortica nell'aorta ascendente"
2015 "Gruppo Nazionale di Bioingegneria" award for original and innovative M.S. Thesis in Biomedical Engineering

Filippo Piatti
"Characterization of the thrombogenic potential of a prototypal polymeric aortic valve: a fluid-structure interaction analysis"
2014 "Gruppo Nazionale di Bioingegneria" award for original and innovative M.S. Thesis in Biomedical Engineering 

Raffaele Ponzini 
“Analisi dei profili dei velocità in un bypass coronarico ad Y tramite un modello multifase"
2002 Fluent User Group Meeting award for the best M.S. Thesis

Emiliano Votta
"Plastica della valvola mitrale mediante tecnica edge-to-edge: analisi biomeccanica degli sforzi sui lembi valvolari"
2001 "Rosanna Degani " award for the best M.S. Thesis in Biomedical Engineering in the cardiovascular field 

 

Collaborations

 

Collaborations


 

Stony Brook University
Biofluids Research Group

Collaborations on: Cardiac device thrombogenicity

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Harvard Medical School
Boston Children's Hospital - Cardiac Surgery

Collaborations on: Simulation of paediatric cardiac surgery

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Mayo Clinic
Cardiovascular Medicine

Collaborations on: Simulation of paediatric cardiac surgery

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Weill Cornell University
Cardiology Department

Collaborations on: Intra-cardiac and aortic flow quantification through 4Dflow analysis

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University of Texas at Austin
Willerson Center for Cardiovascular Modeling & Simulation

Collaborations on: Heart valve computational modeling

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Penn State University
Artificial Heart Lab and Cardiovascular Fluid Dynamics Lab

Collaborations on: Fluid dynamics in left ventricular assist devices

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Leiden University Medical Center
Cardiology, Cardiothoracic Surgery and Vascular Surgery Department

Collaborations on: Image processing, heart valve biomechanics, augmented reality

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Equipment and available technologies

 

Equipment

The Computational Biomechanics Laboratory is part of the CFDHub@POLIMI lab cluster of Politecnico di Milano and is equipped with state-of-the-heart linux nodes for supercomputing activities.

Hardware:

  • 1 cluster of 2 Server SUN Fire X4450 (4 Intel Xeon X7350 @2.93 GHz each) and 2 Server Intel PowerEdge R410 (2 Intel Xeon X5670 @2.93Ghz each)
  • 7 duo-quad workstations (i7 CPUs, 8 GB ram) equipped with general-purpose “Kepler” GPU
  • 3 duo-quad workstations (Xeon5150 CPUs, 4 GB RAM)
  • 1 duo-quad workstation (i7 CPUs, 8 GB RAM) equipped with Nvidia Quadro 2000 GPU for visualization and 3D modeling

Software:

  • Fluid dynamics: ANSYS Fluent
  • Structural mechanics software: ABAQU
  • Fluid Structure Interaction: LS-Dyna
  • Multiphysics: COMSOL

 

Funding

 

CB Lab is grateful to the following funders and partners that have supported our research:

Cariplo Foundation and Regione Lombardia

“SILKELASTOGRAFT - A novel compliance-matching silk fibroin/polyurethane graft for in situ vascular tissue engineering " - (2019-2022)

EU-H2020

“MUltiSectoral Integrative approaches to CArdiac care (MSCA-ITN-2014-642458)” - (2015-2019)

  

Open positions

........ coming soon!

 

Contacts and Location

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Building 21 – Via Golgi 39 – Phone: +39-02-2399-3375

 
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