Organs-on-Chip and Microphysiological Systems
Our passion is to design and exploit microfluidic devices in the fields of basic biological research and translational pharmacological research. Ongoing projects are targeted at the following research areas: microfluidic bioreactors and organs-on-chip
Microfluidic Bioreactors
- Performing single cell trapping, culture and analysis
- Implementing large scale automated microfluidic platforms for high-throughput parallelized screening
- Directing stem cells or iPS cells fate and differentiation through bio-chemical or physical stimuli
Organs-on-Chip
- Heart on a chip: mimicking human cardiac physiology and pathology (cardiac fibrosis, dystrophies) )in vitro through physical (e.g. mechanical & electrical) or chemical (e.g. oxygen concentration gradients) stimulations
- Cartilage and joint on chip: recapitulating human cartilage, bone and joint models to study osteoarthritis
- Endothelial barriers on chip: unraveling the transport mechanisms through physiological barriers such as the blood-brain barrier or the gut endothelium
- Multicompartment microfluidic devices: the ability to generate multicellular tissues separated by neat interfaces allow to build complex human organ models (e.g. joint on chip, blood vessels on chip)