ForCardio Lab

Laboratory of Experimental Micro and Biofluid dynamics

mimiclab

ForcardioLab mission is to support preclinical research in cardiovascular therapies by merging technical and medical knowledge. ForcardioLab has been developing tools which enable realistic and reliable experimental assessment of valvular implants and surgical reparative techniques. Among the custom-made experimental platforms are: a passive beating heart platform housing left portion of the porcine heart, a passive beating heart platform housing right portion of the porcine heart, a pulse duplicator housing aortic root functional unit and a simulator for the coronary flow. The integration of engineering and medical knowledge helped in exploring new possibilities for more complex and thus more realistic platforms. Recently, we performed first trials of restoring the natural contractions of excited porcine heart in so called isolated beating heart apparatus. In the very last years the laboratory focus evolved also in new directions. The experience gained up to now helped in deep understanding of the mechanisms of valvular pathologies and in getting acquainted with the current treatment approaches. In this perspective we are currently extensively using our know-how and apparatuses for studying and developing innovative transcatheter therapies. This experience led to development of our own concept of novel treatments technique. The know-how of the laboratory also attracted valvular therapies developers (both surgical and transcatheter-based). The laboratory has collaborations with R&D departments of world leaders in the field as well as with medical start-ups from all-over Europe. In addition to research oriented activities, Forcardiolab provides training oriented tools to clinicians and companies with the aim of improving skills of the operators performing transcatheter treatments in a hybrid platform, consisting of polymeric models and porcine samples. The same tools have been used with demonstrational purposes at several medical congresses. 

 

 

Research interests

  • Experimental study of the biomechanics of heart valves in ex-vivo models simulating physiological and pathological conditions

  • Study of transcatheter approaches for the treatment of heart disease from the study of the biomechanical interaction of the device with heart structure, to the development of novel approaches

  • Experimental study of surgical approaches to heart valves repair focused on aortic and mitral valve repair techniques and surgical replacement of the valve

  • Development of mock loop for the simulation of the cardiovascular system for research and for physician’s training

 

Team

Faculties  

Riccardo Vismara, PhD

Assistant Professor
Experimental Bio-Fluid Dynamics

Tel.: +39-02-2399-4142
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Gianfranco Beniamino Fiore, PhD

Associate Professor
Experimental Micro- and Bio- Fluid Dynamics

Tel.: +39-02-2399-3337
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Physicians  

 

Riccardo Antona, MD

Cardiac Surgeon

Tel.: +39-02-3904-2334
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Andrea Mangini, MD, PhD

Cardiac Surgeon

Tel.: +39-02-3904-2334
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Guido Gelpi, MD

Cardiac and Vascular Surgeon

Tel.: +39-02-3904-2334
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Monica Contino, MD

Cardiac Surgeon

Tel.: +39-02-3904-2334
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Claudia Romagnoni, MD

Cardiac Surgeon

Tel.: +39-02-3904-2334
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Research Fellows 

Michal Jaworek, PhD

Postdoctoral Fellow
Experimental Bio-Fluid Dynamics

Tel.: +39-02-2399-3327
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Francesca Perico, MSc

Research Fellow
3D printing, Experimental Bio-Fluid Dynamics

Tel.: +39-02-2399-3327
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PhD Students  

 

Eleonora Salurso, MSc

PhD Student
Experimental Bio-Fluid Dynamics

Tel.: +39-02-2399-3327
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Master Students  
 

   Ilaria Nicoli

   Angelica-Gabriella Vezzoli

  Chiara Ceriani

  Rosetta Concoreggi

  Chiara Limonta

Alumni

 2020

 

2019

Eleonora Salurso, MSc

Gianmarco Provaroni, MSc

Cristina Manenti, MSc

Giulia Rottoli, MSc

Francesca Perico, MSc

Claudia Vecchiato, MSc 

Federico Volpari, MSc 

2018

Davide Schiena, MSc

Edoardo Maroncelli, MSc

2017

Ilaria Olivieri, Msc

Yi Peng Bai, Msc

Giulia Parigi, Msc

Giorgia Milotta, MSc

Angela Aversa, MSc

Eleonora Careddu, Msc

2016

Marco Castagna, Msc

Giuliana Lentini, Msc

2015

Federica Sacco, Msc

Luca Vicentini, MSc

2014

Federico Lucherini, Msc

Chiara Asselta, Msc

2012

Moira Pilloni, Msc

Paolo D'Alesio, MSc

 

  

Selected Publications

 

Selected Publications

  1. Jaworek M, Mangini A, Maroncelli E, Rosa R, Salurso E, Votta E, Antona C, Fiore GB, Vismara R Ex Vivo Model of Functional Mitral Regurgitation Using Deer Hearts. J. of Cardiovasc. Trans. Res. 2020, doi: 10.1007/s12265-020-10071-y 
  2. Jaworek M, Pappalardo AO, Selmi M, Gelpi G, Romagnoni C, Lucherini F, Ajmone-Marsan N, Redaelli A, Fiore GB, Votta E, Antona C, Vismara R. Treatment of Tricuspid Regurgitation at Subvalvular Level: Hemodynamic and Morphological Assessment in Ex-Vivo Beating Heart Model. Structural Heart, 2020, 4(1), 36-45, doi: 10.1080/24748706.2019.1686555

  3. Tasca G, Lucherini F, Romagnoni C, Jaworek M, Redaelli A, Antona C, Vismara R. Effect of the valve design on pressure drop, pressure recovery, and spatial positioning of vena contracta. IJAO, 2020, Jul;43(7):468-475. doi: 10.1177/0391398819896582

  4. Jaworek M, Gelpi G, Romagnoni C, Lucherini F, Contino M, Fiore GB, Vismara R, Antona C. Long-arm clip for Transcatheter Edge-to-Edge Treatment of Mitral and Tricuspid Regurgitation – Ex-Vivo Beating Heart Study. Structural Heart, 2019, 3(3), 211-9, doi: 10.1080/24748706.2019.1590666

  5. Tasca G, Beniamino Fiore G, Redaelli P, Romagnoni C, Redaelli A, Gamba A, Antona C, Vismara R. Hydrodynamic and Geometric Behavior of Two Pericardial Prostheses Implanted in Small Aortic Roots. ASAIO J. 2018 Jan/Feb;64(1):86-90. doi: 10.1097/MAT.0000000000000587.

  6. Shah P, Romagnoni C, Jaworek M, Lucherini F, Contino M, Menkis A, Gelpi G, Fiore GB, Antona C, Vismara R. A novel system for the treatment of aortic annular dilation: an ex vivo investigation. Eur J Cardiothorac Surg. 2017 Dec 1;52(6):1090-1097. doi: 10.1093/ejcts/ezx203.

  7. Tasca G, Vismara R, Trinca F, Riva B, Gamba A, Lobiati E. Opening/closing pattern of Trifecta and Freestyle valves versus native aortic valve: Are stentless valves more physiologic than a stented valve? J Card Surg. 2017 Nov;32(11):680-685. doi: 10.1111/jocs.13231. 

  8. Jaworek M, Lucherini F, Romagnoni C, Gelpi G, Contino M, Romitelli P, Antona C, Fiore GB, Vismara R. Modelling of Lesions Associated with Functional Mitral Regurgitation in an Ex Vivo Platform. Ann Biomed Eng. 2017 Oct;45(10):2324-2334. doi: 10.1007/s10439-017-1885-6.

  9. Gelpi G, Romagnoni C, Romitelli P, Vismara R. MitraClip removal: surgical techniques to preserve native mitral valve leaflets. Eur J Cardiothorac Surg. 2017 Oct 1;52(4):818-819. doi: 10.1093/ejcts/ezx205.

  10. Jaworek M, Piola M, Lucherini F, Gelpi G, Castagna M, Lentini G, Antona C, Fiore GB, Vismara R. Functional Tricuspid Regurgitation Model in a Beating Heart Platform. ASAIO J. 2017 Jul/Aug;63(4):438-444. doi: 10.1097/MAT.0000000000000510.

  11. Tozzi P, Hayoz D, Antona C, Fiore GB, Siniscalchi G, Ferrari E, Baeriswyl G, Vismara R. Mastering Mitral Leaflets Coaptation After Valve Repair with Adjustable Mitral Annuloplasty Ring: Proof of Concept in Mock Loop Study. ASAIO J. 2017 Mar/Apr;63(2):168-173. doi: 10.1097/MAT.0000000000000480.

  12. Sturla F, Vismara R, Jaworek M, Votta E, Romitelli P, Pappalardo OA, Lucherini F, Antona C, Fiore GB, Redaelli A. In vitro and in silico approaches to quantify the effects of the Mitraclip® system on mitral valve function. J Biomech. 2017 Jan 4;50:83-92. doi: 10.1016/j.jbiomech.2016.11.013. 

  13. Tasca G, Vismara R, Mangini A, Romagnoni C, Contino M, Redaelli A, Fiore GB, Antona C. Comparison of the Performance of a Sutureless Bioprosthesis With Two Pericardial Stented Valves on Small Annuli: An In Vitro Study. Ann Thorac Surg. 2017 Jan;103(1):139-144. doi: 10.1016/j.athoracsur.2016.05.089. 

  14. Tasca G, Fiore GB, Mangini A, Romagnoni C, Gamba A, Redaelli A, Antona C, Vismara R. Opening-closing pattern of four pericardial prostheses: results from an in vitro study of leaflet kinematics. J Artif Organs. 2016 Dec;19(4):350-356.

  15. Piola M, Vismara R, Tasca G, Lucherini F, Redaelli P, Soncini M, Romagnoni C, Mangini A, Antona C, Fiore GB. Design of a simple coronary impedance simulator for the in vitro study of the complex coronary hemodynamics. Physiol Meas. 2016 Dec;37(12):2274-2285.

  16. Vismara R, Gelpi G, Prabhu S, Romitelli P, Troxler LG, Mangini A, Romagnoni C, Contino M, Van Hoven DT, Lucherini F, Jaworek M, Redaelli A, Fiore GB, Antona C. Transcatheter Edge-to-Edge Treatment of Functional Tricuspid Regurgitation in an Ex Vivo Pulsatile Heart Model. J Am Coll Cardiol. 2016 Sep 6;68(10):1024-33. doi: 10.1016/j.jacc.2016.06.022.

  17. Vismara R, Leopaldi AM, Piola M, Asselta C, Lemma M, Antona C, Redaelli A, van de Vosse F, Rutten M, Fiore GB. In vitro assessment of mitral valve function in cyclically pressurized porcine hearts. Med Eng Phys. 2016 Apr;38(4):346-53. doi: 10.1016/j.medengphy.2016.01.007. 

  18. Gelpi G, Romagnoni C, Vismara R, Mangini A, Contino M, Fiore GB, Antona C. Intracardiac Visualization of Transcatheter Mitral Valve Repair in an In Vitro Passive Beating Heart. Circulation. 2015 Sep 1;132(9):e131-2. doi: 10.1161/CIRCULATIONAHA.115.017519.

  19. Tasca G, Vismara R, Fiore GB, Mangini A, Romagnoni C, Redaelli A, Antona C. A Comprehensive Fluid Dynamic and Geometric Study for an "In-Vitro" Comparison of Four Surgically Implanted Pericardial Stented Valves. J Heart Valve Dis. 2015 Sep;24(5):596-603.

  20. Leopaldi AM, Vismara R, van Tuijl S, Redaelli A, van de Vosse FN, Fiore GB, Rutten MC. A novel passive left heart platform for device testing and research. Med Eng Phys. 2015 Apr;37(4):361-6. doi: 10.1016/j.medengphy.2015.01.013.

  21. Tasca G, Vismara R, Fiore GB, Romagnoni C, Redaelli A, Antona C, Gamba A. Does the type of suture technique affect the fluid-dynamic performance of bioprostheses implanted in small aortic roots? Results from an in vitro study. J Thorac Cardiovasc Surg. 2015 Mar;149(3):912-8. doi: 10.1016/j.jtcvs.2014.10.096.

  22. Tasca G, Vismara R, Fiore GB, Mangini A, Romagnoni C, Pelenghi S, Antona C, Redaelli A, Gamba A. Fluid-dynamic results of in vitro comparison of four pericardial bioprostheses implanted in small porcine aortic roots. Eur J Cardiothorac Surg. 2015 Feb;47(2):e62-7. doi: 10.1093/ejcts/ezu446.

  23. Gelpi G, Romagnoni C, Vismara R, Antona C. Transcatheter aortic valve and valve-in-valve implantation in a beating stenotic porcine aortic valve: intracardiac endoscopic view. Eur J Cardiothorac Surg. 2014 Dec;46(6):1037-8. doi: 10.1093/ejcts/ezu137.

  24. Romagnoni C, Mangini A, Vismara R, Leopaldi AM, Contino M, Lemma MG, Fiore GB, Antona C. Aortic interleaflet triangles reshaping: hydrodynamic, kinematic and morphological effects in in-vitro analysis. J Heart Valve Dis. 2014 Jul;23(4):424-31.

  25. Vismara R, Leopaldi AM, Romagnoni C, Contino M, Mangini A, Stevanella M, Fiore GB, Antona C. In vitro study of a standardized approach to aortic cusp extension. Int J Artif Organs. 2014 Apr;37(4):315-24. doi: 10.5301/ijao.5000316.

  26. Vismara R, Leopaldi AM, Mangini A, Romagnoni C, Contino M, Antona C, Fiore GB. In vitro study of the aortic interleaflet triangle reshaping. J Biomech. 2014 Jan 22;47(2):329-33. doi: 10.1016/j.jbiomech.2013.11.036.

  27. Vismara R, Mangini A, Romagnoni C, Contino M, Redaelli A, Fiore GB, Antona C. In-vitro study of a porcine quadricuspid aortic valve. J Heart Valve Dis. 2014 Jan;23(1):122-6.

  28. Leopaldi AM, Vismara R, Gelpi G, Romagnoni C, Fiore GB, Redaelli A, Lemma M, Antona C. Intracardiac visualization of transcatheter aortic valve and valve-in-valve implantation in an in vitro passive beating heart. JACC Cardiovasc Interv. 2013 Jan;6(1):92-3. doi: 10.1016/j.jcin.2012.07.019

  29. Votta E, Paroni L, Conti CA, Pelosi A, Mangini A, D'Alesio P, Vismara R, Antona C, Redaelli A. Aortic valve repair via neo-chordae technique: mechanistic insight through numerical modelling. Ann Biomed Eng. 2012 May;40(5):1039-51. doi: 10.1007/s10439-011-0497-9.

  30. de Kerchove L, Vismara R, Mangini A, Fiore GB, Price J, Noirhomme P, Antona C, El Khoury G. In vitro comparison of three techniques for ventriculo-aortic junction annuloplasty. Eur J Cardiothorac Surg. 2012 May;41(5):1117-23; discussion 1123-4. doi: 10.1093/ejcts/ezr237

  31. Leopaldi AM, Vismara R, Lemma M, Valerio L, Cervo M, Mangini A, Contino M, Redaelli A, Antona C, Fiore GB. In vitro hemodynamics and valve imaging in passive beating hearts. J Biomech. 2012 Apr 30;45(7):1133-9. doi: 10.1016/j.jbiomech.2012.02.007.

  

Prizes and Honors

 

Journal Awards

Paper of the Month: “Transcatheter Edge-to Edge treatment of Functional Tricuspid Regurgitation in an Ex-Vivo Pulsatile Heart Model”. J Am Coll Cardiol 2016;68:1024-33.
Awarded by Società Italiana di Chirurgia Cardiaca, October, 2016.

Walton Lillehei Young Investigator’s Award: “In vitro comparison of three techniques for ventriculo-aortic junction annuloplasty”, Eur J Cardio-Thor Surg 2011;41(5):1117-24.
Awarded by the European Society of Cardio-Thoracic Surgery, 2011.

 

Conference Awards

Best moderated poster presentation for the topic "Interventions / Peripheral Circulation / Stroke / Surgery", European Society of Cardiology Congress 2017, August 26-30, Barcelona, Spain.

 

  

Collaborations

 

Collaborations


 

University of Manitoba (Winnipeg, MB, Canada)
Division of Cardiac Surgery, Department of Surgery

 

Collaborations on: Development of a novel ring for aortic valve annuloplasty

 


 

ASST Alessandro Manzoni di Lecco
Cardiothoracic Surgery Department

Collaborations on: Evaluation of the biomechanical performances of biological prostheses

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http://www.biomech.polimi.it/images/CB-lab/Logos/lumc_01.png

LivaNova (London, UK)

Collaborations on: Experimental evaluation of novel prostheses for aortic valve treatments

 


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Abbott Vascular (Santa Clara, CA,US)

Collaborations on: Experimental assessment of novel treatments for mitral and tricuspid valve

 


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Tendyne Holdings, Inc (Roseville, MN, US) 

Collaborations on: Experimental assessment of a transcatheter device for standard and off-label applications

 


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Epygon sas (Paris, France)

Collaborations on: experimental study of a transcatheter valve for mitral implantation

 


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Aorticlab Sàrl (Savigny, Switzerland)

Collaborations on: Research activity: development of novel strategies for the transcatheter treatment of the aortic valve

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Kephalios sas (Aix-en-Provence, France)

Collaborations on: experimental studies for the development of a novel device for mitral valve functional regurgitation treatment

 


 

Artiness srl (Milano, Italy)

Collaborations on: Development of holographic numerical models of pathological and treated heart valves


 

Equipment and available technologies

 

Equipment and Available Technology

 

  • Pulse duplicator
  • Systemic and pulmonary criculation impendacne simulators
  • Coronary impendance simulator
  • Echographic system Philips ie33 with transthoracic X5-1 and transesophageal CX7-2t probes
  • Digital high-speed video camera Phantom Miro2, Vision Research.
  • Flowmeter HT110R, Transonic Systems, 1 inch probe (20XL)
  • Flowmeter T403, Transonic Systems, 1/16 inch probes (4PXN)
  • 8 channel signal conditioning system for strain gage applications Vishay A2, with board A2SG8BW
  • Fiberscope (Olympus ENF-GP) and image acquisiotion system (Olympus Visera OTV-s7)

 

Funding

 

ForCardio Lab is grateful to the following funders and partners that have supported our research:

  • Fondazione per la ricerca in Cardiochirurgia ONLUS, Milan, Italy
  • Fondazione Italo Monzino , Milan, Italy

  

Open positions

........ coming soon!

 

Contacts and Location

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Building 21 – Via Golgi 39 – Phone: +39-02-2399-4142

external link: http://www.forcardiolab.it/

 
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