Research interests

The aim of the research at µBS Lab is improving knowledge in the fields of cardiovascular bioengineering, biological fluids treatment, tissue engineering and regenerative medicine. The aims of basic research are then combined with those of applied research, mainly in terms of development and optimization of biomedical devices for lab research and/or for industrial applications.
Specifically, research is devoted the following methodological and technological aspects:

a. Experimental studies of cardiovascular fluid dynamics in physiological, pathological and/or prosthesized conditions

b. Functional analysis and optimization of devices for the treatment of blood (filters, mass and heat exchangers, dialysers, etc.)

c. Design, realization and testing of tissue culture systems for advanced cardiovascular mechanobiology studies and for the regenerative medicine field

d. Complementary topics of biomedical fluid dynamics, such as the study of cerebrospinal fluid treatments and advanced techniques for eye surgery

Team

Faculties
	Gianfranco Beniamino Fiore, PhD Associate Professor Experimental Micro- and Bio- Fluid Dynamics Tel.: +39-02-2399-3337 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
	Monica Soncini, PhD Associate Professor Tissue Engineering Tel.: +39-02-2399-3336 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
	Riccardo Vismara, PhD Associate Professor Experimental Bio-Fluid Dynamics Tel.: +39-02-2399-4142 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Research Fellows
	Michal Jaworek, PhD Research Fellow Experimental Bio-Fluid Dynamics Tel.: +39-02-2399-3327 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
	Francesca Perico, Msc Research Fellow Experimental Bio-Fluid Dynamics Tel.: +39-02-2399-3327 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
PhD Students
	Elia Pederzani, Msc PhD Candidate  Experimental Bio-Fluid Dynamics  Tel.: +39-02-2399-3327 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
	Lorenzo Coppadoro, Msc PhD Candidate Cell and Tissue Bioengineering Tel.: +39-02-2399-3370 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
	Eleonora Salurso, Msc PhD Candidate Experimental Bio-Fluid Dynamics Tel.: +39-02-2399-3327 email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Master Students
	Chiara Roncoroni, Bsc
	Chiara Scrocciolani, Bsc
	Daniele Serino, Bsc
Gian Marco Zaghet, Bsc   Chiara Roncoroni, Bsc   Fabio Pappalardo, Bsc   Chiara Ceriani, Bsc   Rosetta Concoreggi, Bsc   Chiara Limonta, Bsc   Emanuele Sirica, Bsc   Francesco Rota, Bsc   Nicola Nozza, Bsc   Angelica-Gabriella Vezzoli, Bsc   Ilaria Nicoli, Bsc   Martina Mori, Bsc   Benedetta Grossi, Bsc   Silvia Cutuli, Bsc   Anne Cardinaletti, Bsc Alumni 2020 Gianmarco Paci, Msc Giovanni Murgia, Msc Giovanni Piardi, Msc Aldo Suria, Msc Alice Caldiroli, Msc Marco Pezzotta, Msc Giulia Albertini, MSc Ilaria Riccio, MSc Ece Tutsuk, MSc Valeria Capatano, MSc Matilde Quintieri, MSc 2019 Elia Pederzani, Msc Francesca Perico, Msc Giulia Rottoli, Msc Eleonora Salurso, MSc Gianmarco Provaroni, Msc Claudia Vecchiato, Msc Cristina Manenti, MSc Federico Volpari, MSc  2018 Lorenzo Pietro Coppadoro, Msc Beatrice Rossi, Msc Giulia Parigi, Msc Lorenzo Pecoraro, Msc Cecilia Brambilla Pisoni, Msc Edoardo Maroncelli, Msc Davide Schiena, MSc 2017 Michal Bugala, Msc Valentina Caccetta, Msc Ilaria Olivieri, Msc Yi Peng Bai, Msc 2016 Simona Seminati, Msc Giorgia Milotta, Msc 2014 Martina Malavasi, Msc Michela Pin, Msc Alessandra Marzorati, Msc Marco Spiccia, MSc 2013 Emilio Savoldelli, Msc Elena Bresciani, Msc Alice Cambiaghi, PhD Francesco Dal Dosso, MSc 2012 Lorena Casadonte, Msc Nina Bono, PhD Alberto Urban, MSc Claudia Samà, MSc

Selected Publications

Selected Publications

1. Strobel HA, Hookway TA, Piola M, Fiore GB, Soncini M, Alsberg E, Rolle MW. Assembly of Tissue-Engineered Blood Vessels with Spatially Controlled Heterogeneities. Tissue Eng Part A. 2018 Oct;24(19-20):1492-1503. doi: 10.1089/ten.TEA.2017.0492.

2. Suchý T, Šupová M, Bartoš M, Sedláček R, Piola M, Soncini M, Fiore GB, Sauerová P, Kalbáčová MH. Dry versus hydrated collagen scaffolds: are dry states representative of hydrated states? J Mater Sci Mater Med. 2018 Feb 1;29(3):20. doi: 10.1007/s10856-017-6024-2.

3. Bono N, Meghezi S, Soncini M, Piola M, Mantovani D, Fiore GB. A Dual-Mode Bioreactor System for Tissue Engineered Vascular Models. Ann Biomed Eng. 2017 Jun;45(6):1496-1510. doi: 10.1007/s10439-017-1813-9.

4. Piola M, Ruiter M, Vismara R, Mastrullo V, Agrifoglio M, Zanobini M, Pesce M, Soncini M, Fiore GB. Full Mimicking of Coronary Hemodynamics for Ex-Vivo Stimulation of Human Saphenous Veins. Ann Biomed Eng. 2017 Apr;45(4):884-897. doi: 10.1007/s10439-016-1747-7.

5. Ugolini, G. S.; Pavesi, A.; Rasponi, M.; Fiore, G. B.; Kamm, R.; Soncini, M. Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro. Elife 2017 Mar; 6.pii: e22847. doi: 10.7554/eLife.22847
6. Ugolini, G. S.; Rasponi, M.; Pavesi, A.; Santoro, R.; Kamm, R.; Fiore, G. B.; Pesce, M.; Soncini, M. On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain. Biotechnol Bioeng. 2016 Apr;113(4):859-69. doi: 10.1002/bit.25847.

7. Piola M, Prandi F, Fiore GB, Agrifoglio M, Polvani G, Pesce M, Soncini M. Human Saphenous Vein Response to Trans-wall Oxygen Gradients in a Novel Ex Vivo Conditioning Platform. Ann Biomed Eng. 2016 May;44(5):1449-61. doi: 10.1007/s10439-015-1434-0. Epub 2015 Aug 29. Erratum in: Ann Biomed Eng. 2015 Dec;43(12):3040.

8. Piola M, Prandi F, Bono N, Soncini M, Penza E, Agrifoglio M, Polvani G, Pesce M, Fiore GB. A compact and automated ex vivo vessel culture system for the pulsatile pressure conditioning of human saphenous veins. J Tissue Eng Regen Med. 2016 Mar;10(3):E204-15. doi: 10.1002/term.1798.

9. Santoro R, Consolo F, Spiccia M, Piola M, Kassem S, Prandi F, Vinci MC, Forti E, Polvani G, Fiore GB, Soncini M, Pesce M. Feasibility of pig and human-derived aortic valve interstitial cells seeding on fixative-free decellularized animal pericardium. J Biomed Mater Res B Appl Biomater. 2016 Feb;104(2):345-56. doi: 10.1002/jbm.b.33404. 

10. Consolo F, Brizzola S, Tremolada G, Grieco V, Riva F, Acocella F, Fiore GB, Soncini M. A dynamic distention protocol for whole-organ bladder decellularization: histological and biomechanical characterization of the acellular matrix. J Tissue Eng Regen Med. 2016 Feb;10(2):E101-12. doi: 10.1002/term.1767.

11. Piola M, Ruiter M, Vismara R, Mastrullo V, Agrifoglio M, Zanobini M, Pesce M, Soncini M, Fiore GB. Full Mimicking of Coronary Hemodynamics for Ex-Vivo Stimulation of Human Saphenous Veins. Ann Biomed Eng. 2016 Oct 17.

12. Bono N, Pezzoli D, Levesque L, Loy C, Candiani G, Fiore GB, Mantovani D. Unraveling the role of mechanical stimulation on smooth muscle cells: A comparative study between 2D and 3D models. Biotechnol Bioeng. 2016 Oct;113(10):2254-63. doi: 10.1002/bit.25979.

13. Prandi F*, Piola M*, Soncini M, Colussi C, D'Alessandra Y, Penza E, Agrifoglio M, Vinci MC, Polvani G, Gaetano C, Fiore GB, Pesce M. CAdventitial vessel growth and progenitor cells activation in an ex vivo culture system mimicking human saphenous vein wall strain after coronary artery bypass grafting. PLoS One. 2015 Feb 17;10(2):e0117409. doi: 10.1371/journal.pone.0117409. eCollection 2015.

14. Consolo F, Fiore GB, Pelosi A, Reggiani S, Redaelli A. A numerical performance assessment of a commercial cardiopulmonary by-pass blood heat exchanger. Med Eng Phys. 2015 Jun;37(6):584-92. DOI: 10.1016/j.medengphy.2015.03.002.

15. Santoro R, Consolo F, Spiccia M, Piola M, Kassem S, Prandi F, Vinci MC, Forti E, Polvani G, Fiore GB, Soncini M, Pesce M. Feasibility of pig and human-derived aortic valve interstitial cells seeding on fixative-free decellularized animal pericardium. J Biomed Mater Res B Appl Biomater. 2015 Mar 23. DOI: 10.1002/jbm.b.33404.

16. Pietronave S, Zamperone A, Oltolina F, Colangelo D, Follenzi A, Novelli E, Diena M, Pavesi A, Consolo F, Fiore GB, Soncini M, Prat M. Monophasic and biphasic electrical stimulation induces a precardiac differentiation in progenitor cells isolated from human heart. Stem Cells Dev. 2014 Apr 15;23(8):888-98.

17. Piola M, Soncini M, Cantini M, Sadr N, Ferrario G, Fiore GB. Design and functional testing of a multichamber perfusion platform for three-dimensional scaffolds. ScientificWorldJournal. 2013 Dec 23;2013:123974. doi: 10.1155/2013/123974. eCollection 2013.

18. Apicella A, Soncini M, Deriu MA, Natalello A, Bonanomi M, Dellasega D, Tortora P, Regonesi ME, Casari CS. A hydrophobic gold surface triggers misfolding and aggregation of the amyloidogenic Josephin domain in monomeric form, while leaving the oligomers unaffected. PLoS One. 2013;8(3):e58794.

19. Vinci MC, Tessitore G, Castiglioni L, Prandi F, Soncini M, Santoro R, Consolo F, Colazzo F, Micheli B, Sironi L, Polvani G, Pesce M. Mechanical compliance and immunological compatibility of fixative-free decellularized/cryopreserved human pericardium. PLoS One. 2013 May 21;8(5):e64769.

20. Biffi E, Regalia G, Ghezzi D, De Ceglia R, Menegon A, Ferrigno G, Fiore GB, Pedrocchi A. A novel environmental chamber for neuronal network multisite recordings. Biotechnol Bioeng 2012 Oct;109(10):2553-66. doi: 10.1002/bit.24526.

21. Forvi E, Bedoni M, Carabalona R, Soncini M, Mazzoleni P, Rizzo F, O'Mahony C, Morasso C, Cassarà DG, Gramatica F. Preliminary technological assessment of microneedles-based dry electrodes for biopotential monitoring in clinical examinations. Sensor Actuat A Phys. 2012; 180:177-186.

22. Piola M, Soncini M, Prandi F, Polvani G, Fiore GB, Pesce M. Tools and Procedures for Ex Vivo Vein Arterialization, Preconditioning and Tissue Engineering: A Step Forward to Translation to Combat the Consequences of Vascular Graft Remodeling. Recent Pat Cardiovasc Drug Discov. 2012; 7(3):186-195.

Prizes and Honors

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Collaborations

Collaborations

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Equipment and available technologies

Equipment

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Funding

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Open positions

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