MiMic Lab

Microfluidics and Biomimetic Microsystems Laboratory

 

mimiclab

MiMic Lab develops innovative microfluidic technologies for biological applications.

Microscale engineering provides unprecedented opportunities to create cell culture microenvironments that go beyond standard bi- or three-dimensional in vitro models. It also allows great flexibility in the design of microfluidic devices, which can be tailored to the needs of individual cell types and/or cellular co-cultures. Their unique properties make microfluidic bioreactors ideal platforms for advanced cell culture, tissue culture or diagnostics: they are able to recapitulate critical tissue–tissue interfaces, spatiotemporal chemical gradients, and dynamic physical microenvironments of living systems. Recently, microfluidic organs-on-chip have allowed the engineering of in vitro cell microenvironments that resemble human tissue/organ functions found in vivo. This promising field is still in its infancy and leaves room for many exciting questions that need to be addressed. Organ-on-chip technology represents a breakthrough that promises improved alternatives to conventional cell culture models and animal testing.

Research interests

Our passion is to design and exploit microfluidic devices in the fields of basic biological research and translational pharmacological research. Ongoing projects are targeted at the following research areas:

Microfluidic bioreactors

  • Performing single cell trapping, culture and analysis
  • Implementing large scale automated microfluidic platforms for high-throughput parallelized screening
  • Directing stem cells or iPS cells fate and differentiation through bio-chemical or physical stimuli

Organs-on-chip

  • Heart on a chip: mimicking human cardiac physiology and pathology (cardiac fibrosis, dystrophies) )in vitro through physical (e.g. mechanical & electrical) or chemical (e.g. oxygen concentration gradients) stimulations
  • Cartilage and joint on chip: recapitulating human cartilage, bone and joint models to study osteoarthritis
  • Endothelial barriers on chip: unraveling the transport mechanisms through physiological barriers such as the blood-brain barrier or the gut endothelium
  • Multicompartment microfluidic devices: the ability to generate multicellular tissues separated by neat interfaces allow to build complex human organ models (e.g. joint on chip, blood vessels on chip)

Team

Principal Investigator 


Assist. Prof. Marco Rasponi, PhD

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Postdocs 

Paola Occhetta, PhD

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Roberta Visone, PhD

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PhD students


Andrea Mainardi, MSc

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Erika Ferrari, MSc

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Cecilia Palma, MSc

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Mattia Ballerini, MSc

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*working at the Department of Experimental Oncology, IEO

 

 

Federica Colombo, MSc

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*working at the Chromatin Dynamic Unit,

San Raffaele Scientific Institute

 


Carlotta Mondadori, MSc*

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*working at Cell and Tissue Engineering Lab,

IRCCS Galeazzi Orthopaedic Institute

 


Executive PhD students


Michela Polidoro, MSc

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*working at the Epatobiliary Immunnopathology Laboratory, Humanitas Research Hospital

 

Chiara Mancino, MSc

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*working at Center for Musculoskeletal Regeneration at Houston Methodist Research Institute

 

Stefano Serpelloni, MSc

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*working at Center for Musculoskeletal Regeneration at Houston Methodist Research Institute

 

Master Students 

Mohammad Jouybar, BSc

Marcello Ugazio, BSc 

Claudia Caporale, BSc 

Arianna Camilli, BSc 

Silvia Calzuola, BSc 

Sara Corbetta, BSc 

Martina Cassanmagnago, BSc 

Alessandro Cordiale, BSc 

Beatrice Norcini, BSc 

Roberta Cogoni, BSc 

Federico Mariuzzo, BSc 

Alumni 

 

PhD & Postdoc

Daniela Cruz-Moreira, PhD

Giovanni Stefano Ugolini, PhD

Andrea Pavesi, PhD

Francesco Piraino, PhD

Paola Occhetta, PhD

Annalisa Dimasi, PhD

 

2019

Federico Pigoli, MSc

Marco Mondini, MSc

Cecilia Palma, MSc

Stefano Serpelloni, MSc

Stefano Piazza, MSc

Andrea Mazzoleni, MSc

Fabio D'Alessandro, MSc

Tatiana Mencarini, MSc

 

2018

Federico Nebuloni, MSc

Shima Salehi, MSc

Miriam Penati, MSc

Marco Marziani, MSc

Erika Ferrari, MSc

Alessandro Fasani, MSc

Federica Costa, MSc

Francesca Carminati, MSc

 

2017

Pietro Spinelli, MSc

Fabio Stringhi, MSc

Nicolò Monaco, MSc

Andrea Santoleri, MSc

Mattia Ballerini, MSc

Andrea Mainardi, MSc

 

2016

Anna Melesi, MSc

Federico Cantoni, MSc

 

2015

Marta Lemme, MSc

Chiara Conficconi, MSc

Andrea Arneri, MSc 

Elisa Giupponi, MSc

Federica Colombo, MSc

Giorgia Sturla, MSc

Andrea Manelli, MSc

 

2014

Stefania Marchetti, MSc

Lara Marcotti, MSc

 

2013

Andrea Gazaneo, MSc

Mara Licini, MSc

Laura Turco, MSc

Valentina Sala, MSc

Roberta Visone, MSc


Publications

2020

  1. Lopa, S.; Piraino, F.; Talò, G.; Mainardi, V.L.; Bersini, S.; Pierro, M.; Zagra, L.; Rasponi, M.; Moretti, M. Microfluidic biofabrication of 3D multicellular spheroids by modulation of non- geometrical parameters. Frontiers in Bioengineering and Biotechnology 2020 (doi: 10.3389/fbioe.2020.00366).
  2. Roka-Moiia, Y.; Bozzi, S.; Ferrari, C.; Mantica, G.; Dimasi, A.; Rasponi, M.; Santoleri, A.; Scavone, M.; Consolo, F.; Cattaneo, M.; Slepian, M.J.; Redaelli, A. The MICELI (MICrofluidic, ELectrical, Impedance): Prototyping a Point-of-Care Impedance Platelet Aggregometer. International Journal of Molecular Sciences 2020, 21(4): 1174.

2019

  1. Iannielli, A.; Ugolini, G.S.; Cordiglieri, C.; Bido,S.; Rubio, A.; Colasante, G.; Valtorta, M.; Cabassi,T.; Rasponi, M.; Broccoli, V. Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses. Cell Reports 2019, 29: 4646–4656.
  2. Occhetta, P; Mainardi, A.; Votta, E.; Vallmajo-Martin, Q.; Ehrbar, M.; Martin, I.; Barbero, A.; Rasponi, M. Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip modelNature Biomedical Engineering 2019, 3: 545–557.
  3. Marcuzzo, S.; Terragni, B.; Bonanno, S.; Isaia, D.; Cavalcante, P.; Cappelletti, C.; Ciusani, E.; Rizzo, A.; Regalia, G.; Yoshimura, N.; Ugolini, G.S.; Rasponi, M.; Bechi, G.; Mantegazza, M.; Mantegazza, R.; Bernasconi, P.; Minati, L. Hyperexcitability in Cultured Cortical Neuron Networks from the G93A-SOD1 Amyotrophic Lateral Sclerosis Model Mouse and its Molecular Correlates. Neuroscience 2019, 416: 88-99.
  4. Ungaro, F.; Colombo, P.; Massimino, L.; Ugolini, G.S.; Correale, C.; Rasponi, M.; Garlatti, V.; Rubbino, F.; Tacconi, C.; Spaggiari, P.; Spinelli, A.; Carvello, M.; Sacchi, M.; Spanò, S.; Vetrano, S.; Malesci, A.; Peyrin-Biroulet, L.; Danese, S.; D’Alessio, S. Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11International Journal of Cancer 2019, 145(7): 1913-1920.
  5. Visone, R.; Ugolini, G.S.; Vinarsky, V.; Penati, M.; Redaelli, A.; Forte, G.; Rasponi, M. A Simple Vacuum‐Based Microfluidic Technique to Establish High‐Throughput Organs‐On‐Chip and 3D Cell Cultures at the MicroscaleAdvanced Materials Technologies 2019, 4(1):1800319.

2018

  1. Visone, R.; Talò, G.; Occhetta, P.; Cruz-Moreira, D.; Lopa, S.; Pappalardo, O.A.; Moretti, M.; Rasponi, M. A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissuesAPL Bioengineering . 2018, 2:046102.
  2. Visone, R.; Talò, G.; Lopa, S.; Rasponi, M.; Moretti, M. Enhancing all-in-one bioreactors by combining interstitial perfusion, electrical stimulation, on-line monitoring and testing within a single chamber for cardiac constructsScientific Reports  2018, 8:16944.
  3. Occhetta, P.; Pigeot, S.; Rasponi, M.; Dasen, B.; Mehrkens, A.; Ullrich, T.; Kramer, I.; Guth-Gundel, S.; Barbero, A.; Martin, I. Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesisPNAS  2018, 115(18):4625-4630.
  4. Ugolini, G. S.; Occhetta, P.; Saccani, A.; Re, F.; Krol, S.; Rasponi, M.; Redaelli, A. Design and validation of a microfluidic device for blood-brain barrier monitoring and transport studiesJournal of Micromechanics and Microengineering  2018, 28, 044001.
  5. Occhetta, P.; Isu, G.; Lemme, M.; Conficconi, C.; Oertle, P.; Raz, C.; Visone, R.; Cerino, G.; Plodinec, M.; Rasponi, M.; Marsano, A. A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation.  Integrative Biology  2018, 10, 174-183.
  6. Dimasi, A.; Roka-Moiia, Y.; Consolo, F; Rasponi, M.; Fiore, G.B.; Slepian, M.J.; Redaelli, A. Microfluidic flow-based platforms for induction and analysis of dynamic shear-mediated platelet activation - Initial validation versus the standardized hemodynamic shearing deviceBiomicrofluidics  2018, 12(4): 042208.

2017

  1. Ugolini, G. S.; Visone, R.; Redaelli, A.; Moretti, M.; Rasponi, M. Generating Multicompartmental 3D Biological Constructs Interfaced through Sequential Injections in Microfluidic DevicesAdvanced Healthcare Matererials  2017, 6, 1601170.
  2. Giupponi, E.; Visone, R.; Occhetta, P.; Colombo, F.; Rasponi, M.; Candiani, G. Development of a microfluidic platform for high-throughput screening of non-viral gene delivery vectors.Biotechnology and Bioengineering  2017, 115(3):775-784.
  3. Ugolini, G. S.; Visone, R.; Cruz-Moreira, D.; Redaelli, A.; Rasponi, M. Tailoring cardiac environment in microphysiological systems: an outlook on current and perspective heart-on-chip platformsFuture Science OA  2017, 3, FSO191.
  4. Dimasi, A.; Rasponi, M.; Consolo, F.; Fiore, G. B.; Bluestein, D.; Slepian, M. J.; Redaelli, A. Microfludic platforms for the evaluation of anti-platelet agent efficacy under hyper-shear conditions associated with ventricular assist devicesMedical Engineering and Physics  2017, 48, 31–38.
  5. Dimasi, A.; Rasponi, M.; Consolo, F.; Redaelli, A.; Slepian, M. Platelet Membrane-Related Morphologic Alterations: An Early Marker of Supra-Physiologic Shear-Mediated Platelet Activation Associated with VADs. The Journal of Heart and Lung Transplantation  2017, 36, S11–S12.
  6. Ugolini, G. S.; Pavesi, A.; Rasponi, M.; Fiore, G. B.; Kamm, R.; Soncini, M. Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitroElife  2017, 6.

2016

  1. Ugolini, G.; Cruz-Moreira, D.; Visone, R.; Redaelli, A.; Rasponi, M. Microfabricated Physiological Models for In Vitro Drug Screening Applications. Micromachines  2016, 7(12):233.
  2. Zhang Y.S., Arneri A., Bersini S., Shin S.R., Zhu K., Goli-Malekabadi Z., Aleman J., Colosi C., Busignani F., Dell'Erba V., Bishop C., Shupe T., Demarchi D., Moretti M., Rasponi M., Dokmeci M.R., Atala A., Khademhosseini A. Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials 2016, 110:45-59.
  3. Visone, R.; Gilardi, M.; Marsano, A.; Rasponi, M.; Bersini, S.; Moretti, M. Cardiac Meets Skeletal: What’s New in Microfluidic Models for Muscle Tissue EngineeringMolecules  2016, 21, 1128.
  4. Gowran, A.*; Rasponi, M.*; Visone, R.; Nigro, P.; Perrucci, G.L.; Righetti, S.; Zanobini, M.; Pompilio, G. Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells. Stem Cells International 2016, Article ID 4287158, 15 pages
  5. Consolo, F.; Dimasi, A.; Rasponi, M.; Valerio, L.; Pappalardo, F.; Bluestein, D.; Slepian, M. J.; Fiore, G. B.; Redaelli, A. Microfluidic approaches for the assessment of blood cell trauma: a focus on thrombotic risk in mechanical circulatory support devicesJournal of Artificial Organs  2016, 39, 184–193.
  6. Occhetta, P.; Glass, N.; Otte, E.; Rasponi, M.; Cooper-White, J. J. Stoichiometric control of live cell mixing to enable fluidically-encoded co-culture models in perfused microbioreactor arraysIntegrative Biology 2016, 8, 194–204.
  7. Marsano, A.; Conficconi, C.; Lemme, M.; Occhetta, P.; Gaudiello, E.; Votta, E.; Cerino, G.; Redaelli, A.; Rasponi, M. Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissuesLab on a Chip  2016, 16, 599–610.
  8. Occhetta, P.; Licini, M.; Redaelli, A.; Rasponi, M. Design of a microfluidic strategy for trapping and screening single cellsMedical Engineering and Physics  2016, 38, 33–40.
  9. Ugolini, G. S.; Rasponi, M.; Pavesi, A.; Santoro, R.; Kamm, R.; Fiore, G. B.; Pesce, M.; Soncini, M. On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain. Biotechnology and Bioengineering  2016, 113, 859–69.
  10. Russo, L.; Sgambato, A.; Visone, R.; Occhetta, P.; Moretti, M.; Rasponi, M.; Nicotra, F.; Cipolla, L. Gelatin hydrogels via thiol-ene chemistry. Monatshefte fur Chemie. 2016; 147: 587-592.

2015

  1. Dimasi, A.; Rasponi, M.; Sheriff, J.; Chiu, W.-C.; Bluestein, D.; Tran, P. L.; Slepian, M. J.; Redaelli, A. Microfluidic emulation of mechanical circulatory support device shear-mediated platelet activationBiomedical Microdevices  2015, 17, 117.
  2. Rasponi, M.; Gazaneo, A.; Bonomi, A.; Ghiglietti, A.; Occhetta, P.; Fiore, G. B.; Pessina, A.; Redaelli, A. Lab-on-Chip for testing myelotoxic effect of drugs and chemicals. Microfluidics and Nanofluidics  2015, 19, 935–940.
  3. Boccafoschi, F.; Rasponi, M.; Ramella, M.; Ferreira, A. M.; Vesentini, S.; Cannas, M. Short-term effects of microstructured surfaces: role in cell differentiation toward a contractile phenotypeJournal of Applied Biomaterials and Functional Materials  2015, 13, 0–0.
  4. Pavesi, A.; Adriani, G.; Rasponi, M.; Zervantonakis, I. K.; Fiore, G. B.; Kamm, R. D. Controlled electromechanical cell stimulation on-a-chipScientific Reports  2015, 5, 11800.
  5. Occhetta, P.; Centola, M.; Tonnarelli, B.; Redaelli, A.; Martin, I.; Rasponi, M. High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental ProcessesScientific Reports  2015, 5, 10288.
  6. Lopa, S.; Piraino, F.; Kemp, R. J.; Di Caro, C.; Lovati, A. B.; Di Giancamillo, A.; Moroni, L.; Peretti, G. M.; Rasponi, M.; Moretti, M. Fabrication of multi-well chips for spheroid cultures and implantable constructs through rapid prototyping techniquesBiotechnology and Bioengineering  2015, 112, 1457–1471.
  7. Occhetta, P.; Malloggi, C.; Gazaneo, A.; Redaelli, A.; Candiani, G.; Rasponi, M. High-throughput microfluidic platform for adherent single cells non-viral gene deliveryRSC Advances 2015, 5, 5087–5095.
  8. Occhetta, P.; Visone, R.; Russo, L.; Cipolla, L.; Moretti, M.; Rasponi, M. VA-086 methacrylate gelatine photopolymerizable hydrogels: A parametric study for highly biocompatible 3D cell embedding. Journals of Biomedical Materials Research Part A 2015, 103, 2109–2117.

2011-2014

  1. Occhetta, P.; Sadr, N.; Piraino, F.; Redaelli, A.; Moretti, M.; Rasponi, M. Fabrication of 3D cell-laden hydrogel microstructures through photo-mold patterningBiofabrication 2013, 5, 35002.
  2. Pennella, F.; Rossi, M.; Ripandelli, S.; Rasponi, M.; Mastrangelo, F.; Deriu, M. A.; Ridolfi, L.; Kähler, C. J.; Morbiducci, U. Numerical and experimental characterization of a novel modular passive micromixerBiomedical Microdevices 2012, 14, 849–862.
  3. Biffi, E.; Piraino, F.; Pedrocchi, A.; Fiore, G. B.; Ferrigno, G.; Redaelli, A.; Menegon, A.; Rasponi, M. A microfluidic platform for controlled biochemical stimulation of twin neuronal networksBiomicrofluidics 2012, 6, 24106.
  4. Biffi, E.; Menegon, A.; Piraino, F.; Pedrocchi, A.; Fiore, G. B.; Rasponi, M. Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substratesBiotechnology and Bioengineering 2012, 109, 166–175.
  5. Piraino, F.; Camci-Unal, G.; Hancock, M. J.; Rasponi, M.; Khademhosseini, A. Multi-gradient hydrogels produced layer by layer with capillary flow and crosslinking in open microchannelsLab on a Chip 2012, 12, 659–661.
  6. Boccafoschi, F.; Rasponi, M.; Mosca, C.; Bocchi, E.; Vesentini, S. Study of Cellular Adhesion by Means of Micropillar Surface TopologiesAdvanced Materials Research 2011, 409, 105–110.
  7. Rasponi, M.; Piraino, F.; Sadr, N.; Laganà, M.; Redaelli, A.; Moretti, M. Reliable magnetic reversible assembly of complex microfluidic devices: fabrication, characterization, and biological validationMicrofluidics and Nanofluidics 2011, 10, 1097–1107.
  8. Pavesi, A.; Piraino, F.; Fiore, G. B.; Farino, K. M.; Moretti, M.; Rasponi, M. How to embed three-dimensional flexible electrodes in microfluidic devices for cell culture applicationsLab on a Chip 2011, 11, 1593.
  9. Rasponi, M.; Ullah, T.; Gilbert, R. J.; Fiore, G. B.; Thorsen, T. A. Realization and efficiency evaluation of a micro-photocatalytic cell prototype for real-time blood oxygenation. Medical Engineering and Physics 2011, 33, 887–92.

 

Prizes and Honors

Journal Awards

Anna Marsano, Chiara Conficconi, Marta Lemme, Paola Occhetta, Emanuele Gaudiello, Emiliano Votta, Giulia Cerino, Alberto Redaelli, Marco Rasponi.
“Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues” 
One of the top 25 most downloaded articles published in the journal in 2016, and has been included in the Lab on a Chip 2016 Most Downloaded Articles collection.

Giovanni S Ugolini, Marco Rasponi, Andrea Pavesi, Rosaria Santoro, Roger Kamm, Gianfranco B Fiore, Maurizio Pesce, Monica Soncini.
"On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain"  
Cover page of Biotechnology and Bioengineering 2016, 113, 859–69.

Paola Occhetta, Nasser Sadr, Francesco Piraino, Alberto Redaelli, Matteo Moretti, Marco Rasponi.
"Fabrication of 3D cell-laden hydrogel microstructures through photo-mold patterning"  
Selected as part of the 2013 Highlights of Biofabrication.

 

Conference Awards

Roberta Visone, Simona Marzorati, Valeria Perego, Paola Occhetta, Enrico Pesenti, Marco Rasponi.
"uHeart: a beating heart-on-chip platform for on-line recording of functional 3D cardiac microtissues’ electrical activity"
First place in the 2019 Jr. Investigator Poster Contest at the Safety Pharmacology Society 2019 Annual Meeting. September 23-26, 2019, Barcelona, Spain.

Roberta Visone, Andrea Mainardi, Paola Occhetta, Marco Rasponi.
"Beating organs-on-chip as advanced tools in drug screening: engineered in vitro models of human organs and diseases"
Young Scientist Travel Award (YSTA) at the 22nd European Congress on Alternatives to Animal Testing - EUSAAT 2019. October 10-13, 2019, Linz, Austria.

BiomimX Team
"Beating organs on chip advancing drug screening"
Business Plan Competition (BPC) FIRST PRIZE at the Tissue Engineering & Regenerative Medicine International Society (TERMIS) World Congress 2018. September 4-7, 2018, Kyoto, Japan.

Andrea Mainardi, Paola Occhetta, Emiliano Votta, Martin Ehrbar, Ivan Martin, Andrea Barbero, Marco Rasponi.
"Cartilage-on-chip model: Triggering osteoarthritis traits through mechanical compression"
Best poster award in the track “Biomaterials and tissue engineering” at the Sixth National Congress of Bioengineering. June 25-27, 2018, Milano, Italy.

Annalisa Dimasi, Marco Rasponi, Filippo Consolo, Lorenzo Valerio, Gianfranco B Fiore, Danny Bluestein, Marvin I Slepian, Alberto Redaelli.
"Microfluidic emulator of ventricular assist device shear stress patterns: lab-on-a-chip test benches for platelet activation under dynamic device-like shear flow"
Best poster award at the European Society of Biomechanics (ESB) Conference. 5-8 july 2015 Prague, Czech Republic.

 

PhD Thesis Awards

Roberta Visone
"Development of advanced cell culture platforms to engineer and assess functional cardiac in vitro tissue models"
2018 "Gruppo Nazionale di Bioingegneria"
Award "ENZO BELARDINELLI" for original and innovative PhD Thesis in Biomedical Engineering 

Giovanni Stefano Ugolini
"Multi-layer micro devices for advanced cell culture applications"
2017 "Gruppo Nazionale di Bioingegneria"
Award "ALBERTO MAZZOLDI" for original and innovative PhD Thesis in Biomedical Engineering

 

MSc Thesis Awards

Federico Nebuloni
"Development of a continuous flow high-throughput inertial microfluidic device for the filtration of white blood cells nuclei"
2019 "Gruppo Nazionale di Bioingegneria"
Award "Franco Maria Montevecchi, Politecnico di Torino" for original and innovative MSc Thesis in Biomedical Engineering

Miriam Penati
"Development of a mid-throughput microfluidic platform for advanced 3D cell culture: drug screening of iPSC-based cardiac microtissue models"
2018 "Gruppo Nazionale di Bioingegneria"
Award "Laboratorio di Bioingegneria e Bioinformatica, Università di Roma La Sapienza" for original and innovative MSc Thesis in Biomedical Engineering

Chiara Conficconi e Marta Lemme
"Design of a microfluidic device for cyclic mechanical stimulation of three-dimensional cardiac cell constructs"
2015 "Gruppo Nazionale di Bioingegneria"
Award "Laboratory of Biological Structure Mechanics, Politecnico di Milano" for original and innovative MSc Thesis in Biomedical Engineering

Andrea Arneri
"Bioprinting of three-dimensional fibrous scaffolds for cardiac Tissue Engineering"
2015 "Gruppo Nazionale di Bioingegneria"
Award "Franco Maria Montevecchi, Politecnico di Torino" for original and innovative MSc Thesis in Biomedical Engineering

Roberta Visone
"Sviluppo di una camera di coltura per elettrostimolazione e indagine ottica di costrutti tridimensionali in perfusione confinata"
2014 "Gruppo Nazionale di Bioingegneria"
Award "Laboratorio di Modellistica e Controllo di Sistemi Biologici, Università di Padova" for original and innovative MSc Thesis in Biomedical Engineering

 

Collaborations

Collaborations

Cell and Tissue Engineering Lab - IRCCS Istituto Ortopedico Galeazzi, Italy

Humanitas Clinical and Research Center, Italy

Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino, Italy

Chromatin Dynamic Unit, San Raffaele Scientific Institute, Italy

Stem cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Italy

Center for translational medicine, St. Anne’s University Hospital, Czech Republic

Institute for Surgical Research and Hospital Management, University Hospital Basel, Switzerland

Department of Experimental Oncology, IEO - Istituto Europeo di Oncologia, Italy

Center for Biomimetic Medicine, Houston Methodist Research Institute, U.S.A.

 

Equipment and available technologies

Equipment

  • Flow hood for clean operations
  • Plasma cleaner
  • Dessicator
  • Vacuum pumps
  • Precision scaler
  • Spin-coater
  • Oven
  • Syringe pumps
  • Stereomicroscope
  • Control system for digital microfluidic applications

Available technologies

Funding

MiMic Lab is grateful to the following funders supporting our research:

 

EU-H2020

“SINERGIA: advanced technologieS for drug dIscovery and precisioN mEdicine: in vitRo modellinG human physiology and diseAse (MSCA-ITN-2019-860715)” - (2019-2023)

"uKNEEversal: a miniaturized 3D in vitro model of human joint to gain new knowledge on Osteoarthritis pathophysiology (H2020-MSCA-IF-2018" - (2019-2021)

"BrainCircuit-on-chip (ERC-2018-PoC-842423" - (2019-2020)

“MUSICARE: MUltiSectoral Integrative approaches to CArdiac caRE (MSCA-ITN-2014-642458)” - (2014-2018)

Cariplo Foundation

"uKNEEque: a 3D microfluidic osteochondral model to investigate mechanisms triggering age-related joint pathologies and therapeutic effects of bioactive factors produced by nasal chondrocytes" (2019-2022)

“Nanoparticles transport through the blood brain barrier in health and disease” (2014-2017)

“Smart nanostructured hydrogel systems for generation of contractile cardiac organoids” (2013-2016)

“Lab on Chip for testing Myelotoxicity effect of Drugs and chemicals” (2012-2014)

Microfluidic large scale integrated devices with individual chamber control functionalized” (2009-2011)

Italian Ministry of Education, Universities and Research

LMNA-related cardiomyopathy as a paradigm of cardiovascular precision medicine: innovative diagnostic, prognostic and therapeutic approaches” (2017-2019)

Italian Ministry of Health

Cholangiocytes-on-a-chip: a platform to identify medical therapy” (2018-2020)

“Creation of a national network of IIZZSS laboratories involved in the development and application of alternative methods, and in the implementation of the good laboratory practice system” (2017-2018)

“Microfluidic organotypic model of monocyte transendothelial migration to the joint for the screening of promising therapeutic strategies in obese osteoarthritic patients” (2016-2019)

“Development of methodologies alternative to the animal use in the activities of diagnostics and control of biological products in Zooprophylactic Institutes” (2016-2017)

Swiss National Foundation

“A 3D microfluidic osteochondral model to investigate mechanisms triggering osteoarthritis and therapeutic effects of bioactive factors produced by human nasal chondrocytes” (2017-2020)

Open positions

 

We are always looking for brilliant and motivated students to become part of our Team for their Master Thesis project.

 

Contacts and Location

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Building 21 – Via Golgi 39 – Phone: +39-02-2399-3377

@MiMicLab


 
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