Alfonso Gautieri, PhD

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gautieriAlfonso Gautieri has a Master degree in Biomedical Engineering from the Politecnico di Milano (2005) and has obtained the PhD degree in Bioengineering in 2009 with a Thesis on multiscale modelling of collagen tissue. In 2010 he was awarded the Fondazione Rocca postdoctoral fellowship and in 2010-11 he worked at the Laboratory of Atomistic and Molecular Modeling of MIT under the supervision of Prof. Markus Buehler and in the Biomechanics Group at Polimi under the supervision of Prof. Alberto Redaelli. From 2011 to 2016 he worked as postdoctoral fellow at the Bioengineering Department of Polimi and at ETH Zurich (2014-15). Since October 2017 he is Assistant Professor at Politecnico di Milano.   
His research focuses on understanding the mechanics of biomolecules and of biomedical materials starting at the atomistic level by using a computational biology approach. The aim is to further develop the comprehension of the structure-properties relationship in biologic tissues and biomedical materials. This detailed knowledge, based on atomistic information, would help the understanding of the mechanisms underlying pathologic conditions as well as the development of new bio-inspired materials and thus presents an opportunity to institute a new paradigm of bioengineering at the interface of engineering and biology.

Selected publications

Rigoldi, S. Donini, F. Giacomina, F. Sorana, A. Redaelli, T. Bandiera, E. Parisini, A. Gautieri. 2018. Thermal stabilization of the deglycating enzyme Amadoriase I by rational design. Scientific Reports.

Rigoldi, P. Metrangolo, A. Redaelli, A. Gautieri. 2017. Nanostructure and stability of calcitonin amyloids. Journal of Biological Chemistry 292, 7348-7357.

Rigoldi, A. Gautieri, A. Dalle Vedove, A. Luccarelli, S. Vesentini, E. Parisini. 2016. Crystal Structure of the Deglycating Enzyme Amadoriase I in its Free Form and Substrate-bound Complex. Proteins: Structure, Function and Bioinformatics 84, 744-758 (cover paper).

A.K. Nair, A. Gautieri, S.W. Chang and M.J. Buehler. 2013. Molecular mechanics of mineralized collagen fibrils in bone. Nature Communications 4, 1724

Gautieri, S. Vesentini, A. Redaelli, M.J. Buehler. 2011. Hierarchical Structure and Nanomechanics of Collagen Microfibrils from the Atomistic Scale Up. Nano Letters 11, 757-66.